The variation of serum cortisol during ovarian stimulation for<b><i>in vitro</i></b>fertilization

Tica, Vlad Iustin; Marès, P.; Gouzes, Christian; Badea, P.; Popescu, G.; Tica, Irina

doi:10.1080/09513590701325509

Cited by 7 publications

(4 citation statements)

References 36 publications

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“…Nevertheless, FF cortisol levels were independent of peak serum E2 concentrations, consistent with the previous finding that circulating cortisol and E2 levels are unrelated to each other during ovarian stimulation for IVF (48). Yet, FF cortisol levels remained negatively correlated with cumulus cell lipid content, adjusting for patient age and numbers of oocytes retrieved, implying a role for cortisol in ovarian cellular lipid metabolism as shown in other lipid-containing cells (10, 11).…”

Section: Discussionsupporting

confidence: 90%

Intrafollicular cortisol levels inversely correlate with cumulus cell lipid content as a possible energy source during oocyte meiotic resumption in women undergoing ovarian stimulation for in vitro fertilization

Simerman

Hill

Grogan

et al. 2015

Fertility and Sterility

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Objective To determine whether follicular fluid (FF) cortisol levels affect cumulus cell (CC) lipid content during oocyte meiotic resumption and whether CCs express genes for glucocorticoid action. Design Prospective cohort study Setting Academic medical center Patients Thirty-seven non-obese women underwent ovarian stimulation for IVF Intervention(s) At oocyte retrieval, FF was aspirated from the first follicle (>16 mm in size) of each ovary and pooled CC were collected. Main Outcome Measure(s) FF cortisol and cortisone analysis was performed by liquid chromatography-tandem mass spectrometry. CCs were stained with lipid fluorescent dye BODIPY FL C16 to determine lipid content by confocal microscopy. Quantitative real-time PCR was used to detect CC gene expression of 11β-hydroxysteroid dehydrogenase (11βHSD) types 1 and 2, glucocorticoid receptor (NR3C1), lipoprotein lipase (LPL) and hormone sensitive lipase (HSL). Results Adjusting for maternal age, FF cortisol levels negatively correlated with CC lipid content and positively correlated with numbers of total and mature oocytes. CCs expressed genes for 11βHSD type 1 as the predominant 11βHSD isoform, NR3C1, LPL and HSL. Conclusion FF cortisol levels may regulate CC lipolysis during oocyte meiotic resumption and affect oocyte quality during IVF.

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Section: Discussionsupporting

confidence: 90%

Intrafollicular cortisol levels inversely correlate with cumulus cell lipid content as a possible energy source during oocyte meiotic resumption in women undergoing ovarian stimulation for in vitro fertilization

Simerman

Hill

Grogan

et al. 2015

Fertility and Sterility

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“…Some rational reasons for this can be mentioned here. First, previous studies have proven that the supraphysiologic levels of hormones such E 2 , P, and stress hormones (43,44) during the initial ovarian stimulation phase of IVF could lead to morphologic and biochemical modifications and consequently impaired endometrial receptivity with the use of fresh ET as well as affecting the early developing embryo (45), reducing the implantation rates and leading to increased risks of adverse perinatal outcomes (30,46). Next, there is still the increased risk for severe ovarian hyperstimulation syndrome (OHSS), which is a potentially life-threatening serious complication of ovarian stimulation in fresh cycles (47,48).…”

Section: Explanation Of Resultsmentioning

confidence: 99%

Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis

Sha

Yin

Cheng

et al. 2018

Fertility and Sterility

160

118

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Our analysis demonstrated that FET results in lower risks of placenta previa, placental abruption, low birth weight, very low birth weight, very preterm birth, small for gestational age, and perinatal mortality than fresh ET, some differences that are attributed to the increased risks of pregnancy-induced hypertension, large for gestational age, and postpartum hemorrhage. Although cryotechnology keeps improving, for comprehensive consideration, individual approaches remain appropriate to balance the options of FET or fresh ET at present.

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“…We have, also, took care of the possible adverse effect of anticonvulsant therapy -even before the 4 weeks prior the beginning of the study (34). A possible effect of the cortisol, due to high estrogen levels (35) was also avoided.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin Correlation with Bioclinical Benefits of Using Natural Therapeutic Factors in Knee Osteoarthritis

et al. 2017

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Context and objective. The new insights in the pathogenesis of osteoarthritis (OA) reveal the implications of adipocytokines. This study aims to analyze the correlations between the serum value of adiponectin and the clinical rehabilitation effects in patients diagnosed with knee OA, admitted and treated in the complex balneal resort of Techirghiol lake. Subjects and methods. The prospective randomized clinical study included 23 patients in the study group, diagnosed with knee OA according to ACR criteria, and a matching control group of 23 subjects. Serum level of adiponectin (using ELISA technique), uric acid, triglycerides, cholesterol, HDLcholesterol and clinical response using a visual analog scale (VAS) were evaluated in all patients on their admission day and after 10 days of balneal treatment. Control group benefited from the same procedures except for cold mud therapy and mineral water baths. Results. Plasma adiponectin levels (23.73±6.44 ng/dL) were statistically higher (p<0.05) in the study group compared to the control group (18.15±6.49 ng/dL). The mean VAS in both groups was decreased (p<0.005) compared to the initial moment. Conclusions. Cold peloidotherapy combined with physical therapy and balneal factors induces serum adiponectin elevation and improves knee pain in OA. Therapeutic properties of Techirghiol mud still need further research.

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The variation of serum cortisol during ovarian stimulation forin vitrofertilization

Abstract: Cortisol showed a progressive increase beginning from D1, especially after ovulation triggering, and returned to pre-treatment level next month. Cortisol variation was not related to the changes in the E(2) values. Cortisol values at both M-1 and D1 could be used as controls.

Cited by 7 publications

References 36 publications

Intrafollicular cortisol levels inversely correlate with cumulus cell lipid content as a possible energy source during oocyte meiotic resumption in women undergoing ovarian stimulation for in vitro fertilization

Intrafollicular cortisol levels inversely correlate with cumulus cell lipid content as a possible energy source during oocyte meiotic resumption in women undergoing ovarian stimulation for in vitro fertilization

Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis

Adiponectin Correlation with Bioclinical Benefits of Using Natural Therapeutic Factors in Knee Osteoarthritis

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