The vascularization pattern of acellular nerve allografts after nerve repair in Sprague-Dawley rats

Zhu, Zhaowei; Huang, Yanyan; Zou, Xiao-Yan; Zheng, Canbin; Liu, Jianghui; Qiu, Longhai; He, Bo; Zhu, Qian; Liu, Xiaolin

doi:10.1080/01616412.2017.1365423

Cited by 21 publications

(26 citation statements)

References 20 publications

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“…There are three main decellularization protocols for the creation of a functional graft: the one described by Sondell et al (1998) and Hudson et al (2004) , and the combined Hudson protocol added with chondroitinase ABC by Krekoski et al (2001) . SP was used in 33% of the studies ( Jia et al, 2012 , 2017 ; Wang et al, 2012 ; Zhang et al, 2014 ; Zheng et al, 2014 ; Zhou et al, 2014 ; Zhu and Weihua, 2014 ; Huang et al, 2015 ; Garcia-Pérez et al, 2017 ; Zhu et al, 2015 , 2017 ); HP was used in 24% ( Saheb-Al-Zamani et al, 2013 ; Gao et al, 2014a ; Hoben et al, 2015 ; Marquardt et al, 2015 ; Kim et al, 2016 ; Tajdaran et al, 2016 ; Yan et al, 2016 ; Cai et al, 2017 ), and a combined HP was used in 12% ( Whitlock et al, 2009 ; Vasudevan et al, 2014 ; Wood et al, 2014 ; Jiang et al, 2016 ). Other studies (6%) used a FTP with or without the addition of chondroitinase ABC as introduced by Krekoski et al (2001 ; Godinho et al, 2013 ; Wang H. et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

“…Given the importance of this issue, and in order to better understand the process of vascularization in decellularized grafts, we analyzed two studies. Zhu et al (2017) evaluated patterns of microangiogenesis in decellularized grafts, while Farber et al (2016) completed the study by Saheb-Al-Zamani et al (2013) investigating the difference in vascularization between long auto/isografts and decellularized grafts. Zhu et al (2017) studied short grafts (10 mm in length) and demonstrated that nutrient supply relies on fluid permeation from the surrounding tissues during the early stages after the graft procedure.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Nerve Repair Using Decellularized Nerve Grafts in Rat Models. A Review of the Literature

Lovati

D’Arrigo

Odella

et al. 2018

Front. Cell. Neurosci.

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Peripheral nerve regeneration after severe traumatic nerve injury is a relevant clinical problem. Several different strategies have been investigated to solve the problem of bridging the nerve gap. Among these, the use of decellularized nerve grafts has been proposed as an alternative to auto/isografts, which represent the current gold standard in the treatment of severe nerve injury. This study reports the results of a systematic review of the literature published between January 2007 and October 2017. The aim was to quantitatively analyze the effectiveness of decellularized nerve grafts in rat experimental models. The review included 33 studies in which eight different decellularization protocols were described. The decellularized nerve grafts were reported to be immunologically safe and able to support both functional and morphological regeneration after nerve injury. Chemical protocols were found to be superior to physical protocols. However, further research is needed to optimize preparation protocols, including recellularization, improve their effectiveness, and substitute the current gold standard, especially in the repair of long nerve defects.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Nerve Repair Using Decellularized Nerve Grafts in Rat Models. A Review of the Literature

Lovati

D’Arrigo

Odella

et al. 2018

Front. Cell. Neurosci.

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“…A proliferative phase follows, in which the number of inflammatory cells decreases while myofibroblast and endothelial cells increase in correspondence to revascularization. Multiple studies have found almost complete revascularization after 7 days in subcutaneous models, 5,9,[11][12][13] but longer in less vascularized tissues such as breast reconstruction models and tracheal scaffolds. 10,14 Eppley found that subcutaneous revascularization occurred from both surfaces regardless of the orientation of the graft's original basement membrane and that revascularization takes longer to complete when multilayered grafts are used.…”

Section: Discussionmentioning

confidence: 99%

Revascularization of AlloDerm Used during Endoscopic Skull Base Surgery

et al. 2018

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Objectives AlloDerm is an acellular dermal matrix often used for reconstruction throughout the body. AlloDerm has been shown to undergo revascularization when used to reconstruct soft tissue such as in abdominal wall reconstruction. In this study, the authors review the literature on revascularization of AlloDerm and demonstrate the histologic findings of AlloDerm after implantation during skull base reconstruction. Study Design Literature review and case reports. Setting Tertiary Care Institution Participants Patients from a tertiary care institution Main Outcome Measures Histologic slides are evaluated and compared with nonimplanted AlloDerm. Methods The authors review a case of explanted AlloDerm that had been used for skull base reconstruction after endoscopic skull base surgery. Results Upon reviewing the histologic slides of explanted AlloDerm to nonimplanted AlloDerm, we demonstrate revascularization of AlloDerm when used in skull base reconstruction. Representative slides will be included. Conclusions AlloDerm undergoes revascularization when used for skull base reconstruction.

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“…Similar procedures were used in synthesis of PDAPEI polymers as described in our previous work [18,19]. In brief, 2 mmol PDA dissolving in 20 mL DMF were dropwise added into 20 mL DMF containing 1 mmol PEI (1.8 kDa) with vigorous stirring.…”

Section: Synthesis Of Pdapei Polymersmentioning

confidence: 99%

“…With the growth and regeneration of peripheral nerve, metabolic demands are urgently increasing, in which more oxygen and nutrients are needed for the supply, and more waste products need to be removed. In this case, enough blood vessels are of much essence, to exchange nutrients and waste products with outer environment and maintain the viability of new regenerative nerves [16][17][18][19]. Besides that, impressive comparisons in distribution pattern between the nervous and vascular network were made in several studies [12,20,21].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of sciatic nerve regeneration with dual delivery of vascular endothelial growth factor and nerve growth factor genes

Fang

Chen

et al. 2020

J Nanobiotechnol

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Background: Peripheral nerve injury is one common clinical disease worldwide, in which sciatic nerve is anatomically the most challenging to regenerate given its length and large cross-sectional area. For the present, autologous nerve grafting remains to be the most ideal strategy when treating with sciatic nerve injury. However, this method sacrifices healthy nerves and requires highly intensive surgery, still calling for other advanced alternatives for nerve grafting. Results:In this study, we utilized previously well-established gene delivery system to dually deliver plasmid DNA (pDNA) encoding vascular endothelial growth factor (VEGF) and nerve growth factor (NGF), exploring therapeutics for sciatic nerve injury. Low-molecular-weight branched polyethylenimine (bPEI) was constructed as the backbone structure of gene vectors, and it was further crosslinked to synthesize degradable polycations via the conjugation of dialdehydes. Potential synergistic effect between VEGF and NGF proteins were observed on rat sciatic nerve crush injury model in this study. Conclusions:We concluded that dual delivery of plasmid VEGF and NGF as gene therapy could enhance sciatic nerve regeneration. Publisher's NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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The vascularization pattern of acellular nerve allografts after nerve repair in Sprague-Dawley rats

Cited by 21 publications

References 20 publications

Nerve Repair Using Decellularized Nerve Grafts in Rat Models. A Review of the Literature

Nerve Repair Using Decellularized Nerve Grafts in Rat Models. A Review of the Literature

Revascularization of AlloDerm Used during Endoscopic Skull Base Surgery

Enhancement of sciatic nerve regeneration with dual delivery of vascular endothelial growth factor and nerve growth factor genes

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