The vasorelaxant effect and its mechanisms of sodium bisulfite as a sulfur dioxide donor

Meng, Ziqiang; Yang, Zhenhua; Li, Junling; Zhang, Quanxi

doi:10.1016/j.chemosphere.2012.05.056

Cited by 90 publications

(37 citation statements)

References 16 publications

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“…Recently, our research team found that there was an endogenous SO 2 generation pathway in the cardiovascular system [7,8] and that SO 2 played important cardiovascular physiological [7,9,10] and pathophysiological roles [11–16]. In particular, our previous studies [13] showed that in the model of myocardial injury induced by ISO, endogenous myocardial SO 2 generation was significantly reduced.…”

Section: Discussionmentioning

confidence: 99%

The Role of Sulfur Dioxide in the Regulation of Mitochondrion-Related Cardiomyocyte Apoptosis in Rats with Isopropylarterenol-Induced Myocardial Injury

Huang

Liu

Holmberg

et al. 2013

IJMS

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The authors investigated the regulatory effects of sulfur dioxide (SO2) on myocardial injury induced by isopropylarterenol (ISO) hydrochloride and its mechanisms. Wistar rats were divided into four groups: control group, ISO group, ISO plus SO2 group, and SO2 only group. Cardiac function was measured and cardiomyocyte apoptosis was detected. Bcl-2, bax and cytochrome c (cytc) expressions, and caspase-9 and caspase-3 activities in the left ventricular tissues were examined in the rats. The opening status of myocardial mitochondrial permeability transition pore (MPTP) and membrane potential were analyzed. The results showed that ISO-treated rats developed heart dysfunction and cardiac injury. Furthermore, cardiomyocyte apoptosis in the left ventricular tissues was augmented, left ventricular tissue bcl-2 expression was down-regulated, bax expression was up-regulated, mitochondrial membrane potential was significantly reduced, MPTP opened, cytc release from mitochondrion into cytoplasm was significantly increased, and both caspase-9 and caspase-3 activities were increased. Administration of an SO2 donor, however, markedly improved heart function and relieved myocardial injury of the ISO-treated rats; it lessened cardiomyocyte apoptosis, up-regulated myocardial bcl-2, down-regulated bax expression, stimulated mitochondrial membrane potential, closed MPTP, and reduced cytc release as well as caspase-9 and caspase-3 activities in the left ventricular tissue. Hence, SO2 attenuated myocardial injury in association with the inhibition of apoptosis in myocardial tissues, and the bcl-2/cytc/caspase-9/caspase-3 pathway was possibly involved in this process.

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Section: Discussionmentioning

confidence: 99%

The Role of Sulfur Dioxide in the Regulation of Mitochondrion-Related Cardiomyocyte Apoptosis in Rats with Isopropylarterenol-Induced Myocardial Injury

Huang

Liu

Holmberg

et al. 2013

IJMS

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“…TEA attenuated the vasorelaxant effects of SO 2 on endothelium‐intact and ‐denuded rings. The endothelium‐dependent vasorelaxation to low concentrations of SO 2 was blocked in part by iberiotoxin (Zhang and Meng, ; Meng et al, ). Also the protein expression of the channel subunits α and β1 in the BK Ca channel of the rat aorta was up‐regulated by SO 2 application (Zhang et al, ; Zhang et al, ).…”

Section: Sulfur Dioxidementioning

confidence: 99%

Sulfur‐containing gaseous signal molecules, ion channels and cardiovascular diseases

Wen

Jin

Tang

et al. 2017

British J Pharmacology

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“…The main raw materials for sulfur dioxide generation in cells are hydrogen sulfide (H 2 S) and sulfur-containing amino acids3. On account of its functions in many physiological processes and physiopathology, sulfur dioxide was recognized as a new gaseous transmitter4. However, study of sulfur dioxide in living systems is still in its infancy.…”

mentioning

confidence: 99%

“…By now, two detection mechanisms have been reported in the design of fluorescent probes for HSO 3 − /SO 3 2− : reactions with HSO 3 − /SO 3 2− and hydrogen-bond formation with HSO 3 − /SO 3 2345678910111213141516. The reactions with HSO 3 − /SO 3 2− include cleavage of levulinate group1718, nucleophilic addition to aldehyde group1920 or “C=C” double bond2122232425262728293031.…”

mentioning

confidence: 99%

A new fluorescent probe for colorimetric and ratiometric detection of sulfur dioxide derivatives in liver cancer cells

Wang

Cui

et al. 2017

Sci Rep

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A new ratiometric fluorescent probe was constructed with hemicyanine and 7-nitrobenzofurazan for detection of sulfur dioxide derivatives (HSO3−/SO32−). The ratiometric response mode could be attributed to the efficient FRET (Förster resonance energy transfer) platform. The probe exbihited some desirable properties including fast response (within 2 minutes), good selectivity and high sensitivity. Moreover, the probe could detect endogenous HSO3− in liver cancer cells rather than normal liver cells, implying the diagnosal potential of the probe.

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The vasorelaxant effect and its mechanisms of sodium bisulfite as a sulfur dioxide donor

Cited by 90 publications

References 16 publications

The Role of Sulfur Dioxide in the Regulation of Mitochondrion-Related Cardiomyocyte Apoptosis in Rats with Isopropylarterenol-Induced Myocardial Injury

The Role of Sulfur Dioxide in the Regulation of Mitochondrion-Related Cardiomyocyte Apoptosis in Rats with Isopropylarterenol-Induced Myocardial Injury

Sulfur‐containing gaseous signal molecules, ion channels and cardiovascular diseases

A new fluorescent probe for colorimetric and ratiometric detection of sulfur dioxide derivatives in liver cancer cells

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