The vitreomacular interface in different types of age-related macular degeneration

El-Hifnawy, Mohammad A.M.; Ibrahim, Hisham Ali; Gomaa, A.; Elmasry, Mohamed Ashraf

doi:10.18240/ijo.2017.02.11

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Koizumi et al [ 64 ] reported on the evaluation of the VRI with regards to VMT and ERM using SD-OCT [ 64 ]. However, only one study has been reported from a north-eastern African population (Egypt), and only in persons with different types of AMD [ 3 ]. This study is the first report on the VMI from a sub-Saharan African population with or without AMD.…”

Section: Discussionmentioning

confidence: 99%

“…Previous reference to racial differences in the vitreoretinal interface (VRI) was made by Av-Shalom [ 54 ] who suggested that degenerative vitreous changes were rare in Africans compared to Caucasians. To the best of our knowledge, only one report exists on VMI changes and potential associations with AMD in the north-eastern African population, from Egypt [ 3 ], which found no association between VMA and AMD [ 3 ]. The systematic review by Xiao et al [ 55 ] confirmed the lack of studies on the VMI from Africa.…”

Section: Introductionmentioning

confidence: 99%

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Vitreomacular interface abnormalities in the Ghanaian African

Amoaku,

Cushley,

Silvestri

et al. 2023

Eye

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Background/Objective Describe vitreomacular interface abnormalities (VMIA) using spectral-domain optical coherence tomography (SD-OCT), and correlations with age-related macular degeneration (AMD) grade in Ghanaian Africans. Subjects/Methods Prospective, cross-sectional study of adults aged ≥50 years recruited in Ghana AMD Study. Participant demographics, medical histories, ophthalmic examination, digital colour fundus photography (CFP) were obtained. High-resolution five-line raster OCT, Macular Cube 512 × 128 scans, and additional line scans in areas of clinical abnormality, were acquired. SD-OCT VMI features classified by International Vitreomacular Traction Study Group system and relationships to AMD grade were evaluated. Outcomes: VMIA prevalence, posterior vitreous detachment (PVD), vitreomacular adhesions (VMA), vitreomacular traction (VMT), epiretinal membranes (ERM), correlations with AMD grade. Results The full Ghana AMD cohort included 718 participants; 624 participants (1248 eyes) aged ≥50 years (range = 50–101, mean = 68.8), 68.9% female were included in this analysis. CFP with OCT scans were available for 776 eyes (397 participants); 707 (91.1%) had gradable CFP and OCT scans for both AMD and VMI grading forming the dataset for this report. PVD was absent in 504 (71.3%); partial and complete PVD occurred in 16.7% and 12.0% respectively. PVD did not increase with age (p = 0.720). VMIA without traction and macular holes were observed in 12.2% of eyes; 87.8% had no abnormalities. VMIA was not significantly correlated with AMD grade (p = 0.819). Conclusions This provides the first assessment of VMIA in Ghanaian Africans. VMIA are common in Africans; PVD may be less common than in Caucasians. There was no significant association of AMD grade with VMIA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitreomacular interface abnormalities in the Ghanaian African

Amoaku,

Cushley,

Silvestri

et al. 2023

Eye

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“…Some authors consider that alterations of the vitreoretinal interface might play a role in late AMD, 9 – 11 although there is no clear link between these alterations and the presence of large, vascularized PEDs. 12 , 13 Also, many patients with healthy eyes present with vitreomacular adhesion later in life without any pathological implications. 14 As a systemic risk factor, untreated obstructive sleep apnea has been implied in poor response to anti-VEGF.…”

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confidence: 99%

Aflibercept After Ranibizumab Intravitreal Injections in Exudative Age–related Macular Degeneration

Blanco-Garavito

Jung

Uzzan³

et al. 2018

Retina

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Treatment-resistant pigment epithelial detachments can be effectively treated with aflibercept switch therapy. Patients were treated with 3 monthly intravitreal injections and then a Q6 regimen. Mean pigment epithelial detachment height and volume were statistically reduced after the switch at primary endpoint (12 weeks), and best-corrected visual acuity also improved steadily throughout the duration of the study.

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OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review

Metrangolo

Donati

Mazzola

et al. 2021

Journal of Ophthalmology

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Age-related macular degeneration (AMD) is the leading cause of legal blindness in elderly people. Neovascular AMD (nAMD) is responsible for the majority of cases of severe visual loss in eyes with AMD. Optical coherence tomography (OCT) is the most widely used technology for the diagnosis and follow-up of nAMD patients, which is widely used to study and guide the clinical approach, as well as to predict and evaluate treatment response. The aim of this review is to describe and analyze various structural OCT-based biomarkers, which have practical value during both initial assessment and treatment follow-up of nAMD patients. While central retinal thickness has been the most common and one of the first OCT identified biomarkers, today, other qualitative and quantitative biomarkers provide novel insight into disease activity and offer superior prognostic value and better guidance for tailored therapeutic management. The key importance of retinal fluid compartmentalization (intraretinal fluid, subretinal fluid, and subretinal pigment epithelium (RPE) fluid) will be discussed firstly. In the second part, the structural alterations of different retinal layers in various stages of the disease (photoreceptors layer integrity, hyperreflective dots, outer retinal tubulations, subretinal hyperreflective material, and retinal pigment epithelial tears) will be analyzed in detail. The last part of the review will focus on how alterations of the vitreoretinal interface (vitreomacular adhesion and traction) and of the choroid (sub-RPE hyperreflective columns, prechoroidal clefts, choroidal caverns, choroidal thickness and choroidal volume, and choroidal vascular index) interact with nAMD progression. OCT technology is evolving very quickly, and new retinal biomarkers are continuously described. This up-to-date review article provides a comprehensive description on how structural OCT-based biomarkers provide a valuable tool to monitor the progression of the disease and the treatment response in nAMD patients. Thus, in this perspective, clinicians will be able to allocate hospital resources in the best possible way and tailor treatment to the individual patient’s needs.

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The vitreomacular interface in different types of age-related macular degeneration

Abstract: There is an association between posterior vitreous attachment and AMD. There is also an increased incidence of VMA with intra-retinal CNV.

Cited by 4 publications

References 32 publications

Vitreomacular interface abnormalities in the Ghanaian African

Vitreomacular interface abnormalities in the Ghanaian African

Aflibercept After Ranibizumab Intravitreal Injections in Exudative Age–related Macular Degeneration

OCT Biomarkers in Neovascular Age-Related Macular Degeneration: A Narrative Review

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