The water – resistant zeolite imidazolate framework 67 is a viable solid phase sorbent for fluoroquinolones while efficiently excluding macromolecules

Abstract

The determination of antibiotics in biological samples is compromised by their interaction with proteins. It is showed here that the water resistant zeolite imidazolate framework 67 (ZIF-67) represents a useful sorbent for solid-phase extraction (SPE) of fluoroquinolones (FQs) from biological samples. ZIF-67 is unique in possessing permanent nanoscale porosity and a high surface area. As a result, it efficiently excludes proteins from the inner network but can well adsorb small organic molecules. Its extraction capacity for FQs exceeds that of isostructural ZIF-8, probably due to high affinity for Co(II) ions in ZIF-67. The findings were exploited to design a method for the analysis of FQs, which were extracted from bio-samples by ZIF-67 via SPE. Following elution of the absorbed FQs with NaOH/methanol, they were quantified by HPLC with diode array detection. The assay has a wide linear range that extends from 3.9 to 4000 μg⋅kg‾ 1 , with detection limits between 1.2 and 2.9 μg⋅kg‾ 1 . The method was successfully applied to the determination of FQs in manure.

A water-stable lanthanide metal-organic framework for fluorimetric detection of ferric ions and tryptophan

“…Metal-organic frameworks (MOFs) constitute a group of attractive hybrid materials with interesting applications such as gas separation [ 11 ] and storage [ 12 ], extraction/preconcentration [ 13 ], sensing [ 14 , 15 ], drug delivery [ 16 ], and catalysis [ 17 ]. They have also been explored for luminescence applications [ 18 ].…”

Magnetic solid-phase extraction of pyrethroid insecticides from tea infusions using ionic liquid-modified magnetic zeolitic imidazolate framework-8 as an adsorbent

“…16 ZIFs are microporous with high surface areas and uniform structured cavities, which endow them with remarkable physical, chemical, and thermal stabilities and excellent adsorption abilities. 17,18 Among the different types of ZIFs, ZIF-8 has attracted widespread attention because of its high surface area, hierarchical porosity, easy preparation and costeffectiveness. Recently, ZIF-8 has been widely employed in gas storage, drug delivery, sensing, catalysis, and mixed matrix membranes.…”

Novel Zeolitic Imidazolate Frameworks Based on Magnetic Multiwalled Carbon Nanotubes for Magnetic Solid-Phase Extraction of Organochlorine Pesticides from Agricultural Irrigation Water Samples

“…Owing to their features of microporosity, uniform structured cavities, and a high surface area, ZIFs have many applications, such as chemical pollutant removal [29,30], chromatographic separation [31,32], and drug delivery [33]. ZIF-67 is a recently developed ZIF compound that has the formula Co(Hmim) 2 (mim = 2-methylimidazole) with a sodalite-related zeolite type structure [34]. Because of the low coordination of the Co cation, ZIF-67 has three times higher adsorption capacity for dye from aqueous solutions than ZIF-8 [35].…”