2015
DOI: 10.1016/j.mattod.2014.07.009
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The winding road for carbon nanotubes in nanomedicine

Abstract: Carbon nanotubes (CNTs) are recognized as promising nanomaterials for technological advancement. However, the stigma of structural similarity with asbestos fibers has slowed down progress of CNTs in nanomedicine. Nevertheless, it also prompted thorough studies that have revealed that functionalized CNTs (fCNTs) can biologically behave in a very different and safer manner. Here we review pristine and fCNT fate in biological settings, focusing on the importance of protein interaction, formation of the protein co… Show more

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Cited by 126 publications
(86 citation statements)
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“…The risk of CNPs triggering an immune response should be also considered, since the protein components of the complement system can bind to carbon nanotubes. Certain studies have focused on how the functionalization of carbon nanoparticles, often with protein coronas, can attenuate or abate the immune response of nanoparticles in biological applications [88]. Such studies are particularly promising in suggesting that the fate, toxicity, lifetime, and therefore the utility of CNPs is highly tunable and can be engineered by the user via the nanoparticle corona.…”
Section: Toxicity Of Delivered Swcnt-protein Conjugatesmentioning
confidence: 99%
“…The risk of CNPs triggering an immune response should be also considered, since the protein components of the complement system can bind to carbon nanotubes. Certain studies have focused on how the functionalization of carbon nanoparticles, often with protein coronas, can attenuate or abate the immune response of nanoparticles in biological applications [88]. Such studies are particularly promising in suggesting that the fate, toxicity, lifetime, and therefore the utility of CNPs is highly tunable and can be engineered by the user via the nanoparticle corona.…”
Section: Toxicity Of Delivered Swcnt-protein Conjugatesmentioning
confidence: 99%
“…In a recent study by Nowacki et al [94], HIPEC was performed in mice using a nano-sized drug delivery system based on carbon nanotubes (CNTs) [95]. Briefly, CNTs loaded with cisplatin were functionalized with the anti-CD133 antibody to reduce the resistance to chemotherapy, emerging from the CD133 antigen.…”
Section: Strategies For Ip Delivery and Sustained Release Of Nanomedimentioning
confidence: 99%
“…These barriers tightly seal the central nervous system (CNS) from the changeable milieu of blood. The presence of these barriers restricts drug delivery to the CNS leading to inefficient and ineffective diagnosis and therapy of neurological disorders [22,23]. There is a promise that nanotechnology will revolutionize neurological disease diagnosis and treatment [3].…”
Section: Carbon Nanotubes In the Diagnosis And Treatment Of Central Nmentioning
confidence: 99%