The Wound Healing Response After Laser In Situ Keratomileusis and Photorefractive Keratectomy

Wilson, Steven E.; Mohan, Rahul; Hong, Jong Wook; Lee, Jong Soo; Choi, Rosan; Mohan, Rajiv R.

doi:10.1001/archopht.119.6.889

Cited by 150 publications

(39 citation statements)

References 29 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous research suggests that the epithelial flap serves as an effective barrier that protects the bare surface of the stroma from inflammatory or growth factors, such as transforming growth factor-β, which reduced the stromal haze level [24,25]. However, the present studies showed that the difference between the two groups is statistically insignificant at 3 months or more postoperatively.…”

Section: Discussioncontrasting

confidence: 78%

Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Feng

Chen²,

Stojanović³

et al. 2011

Ophthalmologica

View full text Add to dashboard Cite

Objective: To examine possible differences in clinical outcomes between off-flap and on-flap epipolis laser in situ keratomileusis (epi-LASIK) for myopia. Methods: Pertinent studies were selected by extensive searches. A total of 9 studies reporting on a total of 958 eyes were included in the present meta-analysis. Statistical analysis was performed using RevMan 5.0 software. Results: There were no significant differences in the final refractive spherical equivalent (p = 0.38), manifest refractive spherical equivalent within ±0.50 D of the target (p = 0.76), final uncorrected visual acuity (p = 0.90), loss of ≧1 line of best spectacle-corrected visual acuity (p = 0.99), and corneal haze at 3 months postoperatively (p = 0.96) or more than 6 months (p = 0.64). More patients felt severe pain in the on-flap group than in the off-flap group, although this finding was not statistically significant (p = 0.05). However, off-flap epi-LASIK had a better mean uncorrected visual acuity at 3 days (p = 0.04) and 5 days (p = 0.01), and faster re-epithelialization (p < 0.00001) after surgery. Conclusions: According to the available data, off-flap and on-flap epi-LASIK had equal visual and refractive outcomes for the treatment of myopia. Off-flap epi-LASIK had more rapid re-epithelialization and visual recovery compared to on-flap epi-LASIK.

show abstract

Section: Discussioncontrasting

confidence: 78%

Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Feng

Chen²,

Stojanović³

et al. 2011

Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…The process of apoptosis was accompanied by an activation of adjacent healthy keratocytes, which repopulated the affected region of the corneal stroma. 28 Corneal collagen cross-linking treatments have been performed on human patients in Europe, for approximately 10 years, with promising results. 2,[11][12][13][14] The durability of this strengthening effect is unknown.…”

Section: Discussionmentioning

confidence: 99%

Corneal Collagen Cross-Linking: A Confocal, Electron, and Light Microscopy Study of Eye Bank Corneas

Dhaliwal

Kaufman

2009

Cornea

View full text Add to dashboard Cite

Based on clinical studies, corneal cross-linking is a promising treatment that appears to be safe and to halt ectatic corneal disease progression. Initial European studies used animal models to extrapolate human protocols. In conjunction with clinical studies, we believe that human ex vivo corneal studies provide a means to evaluate the structural and morphological changes associated with this procedure, within human corneas, in a manner that cannot be accomplished in vivo.

show abstract

“…This accumulation may be considered as a sign of enhanced biosynthetic activity and a delayed transfer along the secretory route. Proliferating keratocytes called myofibroblasts produces disorganized collagen and growth factors to stimulate healing [14,42]. The cell appearance found in a specimen several 276 Fig.…”

Section: Discussionmentioning

confidence: 99%

Electron microscopic and immunohistochemical examination of scarred human cornea re-treated by excimer laser

Bleckmann

Schnoy

Kresse

2002

Graefe's Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

The Wound Healing Response After Laser In Situ Keratomileusis and Photorefractive Keratectomy

Cited by 150 publications

References 29 publications

Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Comparison of Clinical Outcomes between ‘On-Flap’ and ‘Off-Flap’ Epi-LASIK for Myopia: A Meta-Analysis

Corneal Collagen Cross-Linking: A Confocal, Electron, and Light Microscopy Study of Eye Bank Corneas

Electron microscopic and immunohistochemical examination of scarred human cornea re-treated by excimer laser

Contact Info

Product

Resources

About