The X­Ray Repair Cross Complementing 1(XRCC1) Rs25487 Variation and Susceptibility to Cirrhosis in Patients with Chronic Hepatitis C Virus

Abstract

Background: Around 130-170 million individuals are thought to be affected with the hepatitis C virus (HCV), which is a viral pandemic and the leading cause of persistent liver illness. The frequency of HCV infections is greatest in Egypt, where more than 10% of the general population is affected. Objective: The purpose of the current study was to confirm any potential associations between cirrhosis and the XRCC1 rs25487 variant in chronic HCV patients. Patients and methods: A fibroscan was conducted on 80 HCV +ve patients and 40 control participants for a total of 120 people to determine the extent of hepatic fibrosis. Real-time PCR was used to examine the SNP genotyping in the XRCC1 gene (rs25487). Results: There were no substantial variation in the prevalence of different genotypes in XRCC1 A > G (GG and AG) between non cirrhotic and cirrhotic in chronic HCV Egyptian patients. Conclusion: By comparing the incidence of the various genotypes (AA, AG, and GG) in the analyzed groups, no clear pattern of relationship could be seen (p=0.225). (P = 0.410) There was no distinguishable pattern of connection between the AA genotype and the other genotypes (GG and AG). Comparing the frequencies of the two alleles (A and G alleles) in the three groups under study revealed no evidence of a connection.