TheB locus (MHC) in the chicken: Association with the fate of RSV-induced tumors

Collins, W. M.; Briles, W. E.; Zsigray, Robert M.; Dunlop, W.; Corbett, A. C.; Clark, Kathy K.; Marks, James L.; McGRAIL, T. P.

doi:10.1007/bf01570490

Cited by 137 publications

(79 citation statements)

References 46 publications

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“…Scores were defined weekly as follows: 0 = no palpable tumor; 1 = tumor up to 1 cm 3 ; 2 = tumor between 1 and 5 cm 3 ; 3 = tumor between 5 and 25 cm 3 ; 4 = tumor between 25 and 50 cm 3 ; 5 = tumor between 50 and 100 cm 3 ; 6 = tumor over 100 cm 3 ; 7 = death during the experiment. The scores were used to assign a tumor profile index (TPI) as slightly modified from Collins et al [10]: 5 = a terminal tumor at 35 days PI; 4 = terminal tumor at 49 days PI; 3 = terminal tumor at 63 days PI; 2 = tumor up to 1 cm 3 ; 1 = otherwise (tumor less than 1 cm 3 , no tumor or complete regression by the end of the experiment).…”

Section: Recorded Resistance Traits: Tpi Mortality Time Of Deathmentioning

confidence: 99%

“…Indeed, early studies on RSV stipulated that only a very restricted number of genes and even one single gene would be involved in the control of tumor regression or progression. This was in some cases because of the easiness to select for the trait or because of the observation of the segregation of different phenotypes [21] or because of the particular genetic background of some inbred lines used intensively for the study of the fate of RSV tumors [10,33,39]. Naturally, most of the studies on RSV tumor control consider MHC as the natural candidate of choice as far as disease resistance is concerned, and showed an effect of the avian B-complex on either the progression or regression, as reviewed by Schierman and Collins [38].…”

Section: Introductionmentioning

confidence: 99%

“…Some major differences between genotypes in a given background have often been shown. For example, in an F2 cross of two highly inbred lines homozygous for B 2 and B 5 , the most resistant genotype (B 2 B 2 ) showed 5% of mortality and a mean Tumor Profile Index (TPI) of 2.94 and the most susceptible genotype (B 5 B 5 ) showed a 93% mortality and a mean TPI of 4.93 whereas the heterozygote showed values closer to the resistant genotype than to the susceptible one [10]. Even if all the studies performed were not able to distinguish a possible direct effect from a closely linked effect, some clearly proved, using several recombinants in different backgrounds, that the genetic control is associated with the B−F/B−L region rather than with the B−G one [1,2,33].…”

Section: Introductionmentioning

confidence: 99%

“…Most reports studying the effect of MHC on the fate of RSV tumors were conducted from comparisons between congenic inbred lines or crosses between inbred lines, the possible amount of genetic variability expressed. Some of these studies, however, allowed at the same time to show evidence for non-MHC variation in the control of tumor fate when genetic background was found to play a major role [10][11][12]. Using backcrosses from three partially congenic inbred lines, Cutting et al [14] and Plachy [32] showed that resistance to RSV is the result of complementing action of MHC (or MHC-linked) genes and genes outside the MHC.…”

Section: Introductionmentioning

confidence: 99%

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Genetic analysis of a divergent selection for resistance to Rous sarcomas in chickens

et al. 2004

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-Selection for disease resistance related traits is a tool of choice for evidencing and exploring genetic variability and studying underlying resistance mechanisms. In this framework, chickens originating from a base population, homozygote for the B 19 major histocompatibility complex (MHC) were divergently selected for either progression or regression of tumors induced at 4 weeks of age by a SR-D strain of Rous sarcoma virus (RSV). The first generation of selection was based on a progeny test and subsequent selections were performed on full-sibs. Data of 18 generations including a total of 2010 birds measured were analyzed for the tumor profile index (TPI), a synthetic criterion of resistance derived from recording the volume of the tumors and mortality. Response to selection and heritability of TPI were estimated using a restricted maximum likelihood method with an animal model. Significant progress was shown in both directions: the lines differing significantly for TPI and mortality becoming null in the "regressor" line. Heritability of TPI was estimated as 0.49 ± 0.05 and 0.53 ± 0.06 within the progressor and regressor lines respectively, and 0.46 ± 0.03 when estimated over lines. Preliminary results showed within the progressor line a possible association between one Rfp-Y type and the growth of tumors.chicken / selection / resistance / Rous sarcoma / Rfp-Y † This article is dedicated to the memory of Pierrick Thoraval

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Section: Recorded Resistance Traits: Tpi Mortality Time Of Deathmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genetic analysis of a divergent selection for resistance to Rous sarcomas in chickens

et al. 2004

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“…Resistance to many diseases in chickens has been shown to be under genetic control associated with the major histocompatibility B complex (MHC) (Bacon et al 1981, Briles et al 1983, Clare et al 1986, Collins et al 1977, Schierman et al 1977. The etiological agents involved in the studies were viral or parasitic nonbacterial pathogens.…”

Section: Introductionmentioning

confidence: 99%

Genetic resistance to fowl cholera is linked to the major histocompatibility complex

1987

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Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for resistance to fowl cholera by challenge with Pasteurella multocida strain X73. Control of the response at high doses was associated in a preliminary study with Ir-GAT and response to RSV tumors. Genetic control of resistance to low doses of P. multocida was demonstrated via sublines and F2 segregants to be linked with genes of the B-Gregion. Thus, genetic control of resistance to fowl cholera in chickens after exposure to Pasteurella multocida was shown to be linked to the major histocompatibility B complex, in this first demonstration of MHC-linked resistance to bacterial disease challenge.

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Molecular and immunogenetic analysis of major histocompatibility haplotypes in northern bobwhite enable direct identification of corresponding haplotypes in an endangered subspecies, the masked bobwhite

et al. 1999

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The major histocompatibility complex (MHC) is a group of genetic loci coding for haplotypes that have been associated with fitness traits in mammals and birds. Such associations suggest that MHC diversity may be an indicator of overall genetic fitness of endangered or threatened species. The MHC haplotypes of a captive population of 12 families of northern bobwhites (Colinus virginianus) were identified using a combination of immunogenetic and molecular techniques. Alloantisera were produced within families of northern bobwhites and were then tested for differential agglutination of erythrocytes of all members of each family. The pattern of reactions determined from testing these alloantisera identified a single genetic system of alloantigens in the northern bobwhites, resulting in the assignment of a tentative genotype to each individual within the quail families. Restriction fragment patterns of the DNA of each bird were determined using the chicken MHC B‐G cDNA probe bg11. The concordance between the restriction fragment patterns and the alloantisera reactions showed that the alloantisera had identified the MHC of the northern bobwhite and supported the tentative genotype assignments, identifying at least 12 northern bobwhite MHC haplotypes. Eighteen northern bobwhite alloantisera were then used to detect a minimum of 17 masked bobwhite MHC haplotypes. Subsequent restriction fragment pattern analyses using cDNA probes for chicken MHC genes were in agreement with agglutination patterns displayed by the antisera, showing that the immunogenetically identified alloantigen system constituted the MHC of the masked bobwhite. These data demonstrate that a non‐endangered species may be used to provide antisera for differentiating MHC haplotypes in a closely related endangered species, thus providing a practical basis for long‐range monitoring of MHC haplotypes of birds surviving in their native habitats. Zoo Biol 18:279–294, 1999. © 1999 Wiley‐Liss, Inc.

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TheB locus (MHC) in the chicken: Association with the fate of RSV-induced tumors

Cited by 137 publications

References 46 publications

Genetic analysis of a divergent selection for resistance to Rous sarcomas in chickens

Genetic analysis of a divergent selection for resistance to Rous sarcomas in chickens

Genetic resistance to fowl cholera is linked to the major histocompatibility complex

Molecular and immunogenetic analysis of major histocompatibility haplotypes in northern bobwhite enable direct identification of corresponding haplotypes in an endangered subspecies, the masked bobwhite

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