According to the United Nations, 70% of the world’s population will live in cities by 2050. This growth will be reflected in the demand for better services that should be adjusted to the collective and individual needs of the population. Governments and organizations are working on defining and implementing strategies that will enable them to respond to these challenges. The main challenges are related to transport and its management, considering transportation as a core issue in the economy, sustainability, and development of the regions. In this way, the Intelligent Transportation Systems (ITS) play a key role in the response to these scenarios, being that they are the framework where the new hardware and software tools are integrated, allowing an efficient development of transportation systems management, attending to aspects such as: traffic management, communications between vehicles and infrastructures, and security, among others. Nevertheless, the concept of ITS evolves rapidly so it is necessary to understand its evolution. To do that, the current research develops a thematic analysis of ITS in literature, evaluating the intellectual structure and its evolution using SciMAT, quantifying the main bibliometric performance indicators, and identifying the main research areas, authors, journals, and countries. To this purpose, the publications related to ITS from 1993 to 2019 available in the Web of Science (WoS) Core Collection were retrieved (7649 publications) and analyzed. Finally, one of the main results is the latest research themes map of ITS, considering its intellectual structure, evolution, and relationship. It assists in the definition and implementation of strategies, the identification of the scientific, academic, and business opportunities, and future research lines to consolidate the role of ITS in the new city models.