Theoretical and Experimental Approaches to Generalized Autoimmunity

Co-encapsulation of an antigen and CpG oligonucleotides into PLGA microparticles by TROMS technology

“…Despite CpG sequences are under clinical trials, some authors have reported adverse effects such as splenomegaly, lymphadenopathy [29] or the activation of autoimmune responses [30] in animal models after the administration of high doses of CpG motifs (over than 100 µg). In this context, the particle would protect both molecules from degradation so it would not be necessary to administer a high amount of CpG sequences.…”

Immune ablation followed by allogeneic or autologous bone marrow transplantation: A new treatment for severe autoimmune diseases?

“…Among the over 40 disorders recognized at present as having an autoimmune pathogenesis [ 1 , 21 there are a significant number of severe diseases which can only be partially controlled by the customary long-term immunodepressive therapy, which has not abolished the "significant sum of human misery" [3] that is inevitably associated with the diseases and their treatment, Taking systemic lupus erythematosus (SLE) as a prototype of generalized autoimmune diseases [4], even with some reservations [l], there exists an entire spectrum of negative consequences of long-term immunodepressive and corticosteroid therapy, including opportunistic infections, coronaropathies, avascular necrosis of bones and neuropsychological cognitive dysfunctions. This has been regarded as the "price of therapy" [5], and a "damage index" has been proposed.…”

Epstein-Barr virus-induced autoimmune responses. II. Immunoglobulin G autoantibodies to mimicking and nonmimicking epitopes. Presence in autoimmune disease.

“…Antibody alone can do this. As has been demonstrated for other autoantibodies (12)(13)(14)(15), the anti-p542 response probably begins with polyreactive early B cells with low affinity sIgM. For anti-p542, the polyreactivity must include cross-reactivity between configurations in the gly/ala repeat of EBNA-1 and configurations in the Gly- .…”