2002
DOI: 10.1093/chromsci/40.5.234
|View full text |Cite
|
Sign up to set email alerts
|

Theoretical and Practical Aspects of Fast Gas Chromatography and Method Translation

Abstract: Interest in the development and implementation of fast gas chromatography (GC) methods continues to increase. Fast GC method development and validation can be simplified and more successful if a few key theoretical and practical concepts are kept in mind. Key concepts such as speed-optimized flow rate, optimal temperature-program rate, sample capacity, "cut the column", and principles of method translation are discussed.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
50
0
3

Year Published

2004
2004
2022
2022

Publication Types

Select...
6
1
1

Relationship

0
8

Authors

Journals

citations
Cited by 127 publications
(55 citation statements)
references
References 23 publications
2
50
0
3
Order By: Relevance
“…Theoretical and practical aspects of method translation, where the aim is to produce a scaled version of the original chromatogram, have been developed by Blumberg and co-workers [7,8]. The usefulness of method translation for fast GC analysis of nutmeg and lemon essential oils has been reported [9].…”
Section: Introductionmentioning
confidence: 99%
“…Theoretical and practical aspects of method translation, where the aim is to produce a scaled version of the original chromatogram, have been developed by Blumberg and co-workers [7,8]. The usefulness of method translation for fast GC analysis of nutmeg and lemon essential oils has been reported [9].…”
Section: Introductionmentioning
confidence: 99%
“…The reduction of column I.D. is usually combined with strategies as: changing column geometry (column shortening approach, thinner stationary phase), or its operating parameters (higher heating rates, above optimum carrier gas flow rate and in some cases usage of hydrogen as a carrier gas) what corresponds to the theoretical concept for the practical optimization of analysis speed of routine fast GC proposed by Klee & Blumberg, 2002. Theory of capillary gas chromatography has already demonstrated that the application of narrow-bore capillary columns has a number of advantages.…”
Section: Narrow-bore Columnsmentioning
confidence: 99%
“…The two columns have the same phase ratio and the same separation power (length to I.D. ratio) to allow the method translation with preserved resolution (Klee & Blumberg, 2002). 0.1 mm I.D.…”
Section: Narrow-bore Columnsmentioning
confidence: 99%
See 1 more Smart Citation
“…Small diameter GC capillary columns (< 0.1 mm inner diameter) provide high efficiency, and thus the column length can be shortened to decrease the analysis time without sacrificing the separation performance. Other ways to improve speed of a GC analysis were to increase the gas flow rate, increase the heating rate programmed in the GC oven, decrease the thickness of the stationary phase and using detector systems that are tolerant of high pressures [183]. ThermoFinnigan [180,184] as well as other wellknown liquid and gas chromatographic manufacturers [185] have developed ultra-fast GC systems that have good separation with comparable performance as that of a conventional GC system.…”
Section: High Speed Gas Chromatographymentioning
confidence: 99%