Theoretical framework to evaluate antioxidant synergistic effects from the coextraction of marjoram, rosemary and parsley

Villanueva-Bermejo, David; Siles-Sánchez, María de las Nieves; Martín Hernández, Diego; Rodríguez García-Risco, Mónica; Jaime, Laura; Santoyo, Susana; Fornari, Tiziana

doi:10.1016/j.foodchem.2023.137919

Cited by 10 publications

(7 citation statements)

References 38 publications

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“…Evaluation of antioxidant activity was carried out to determine DPPH and ABTS free radical scavenging rate in 15 batches of Piperis Herba and 15 batches of Piperis Kadsurae Caulis. DPPH and ABTS free radical scavenging assays were carried out based on a methodology from the literature [ 11 , 12 ], and a comparison was made by integrating the different origins of Piperis Herba and the origin source with the most significant antioxidant activity of the origin source of Piperis Kadsurae Caulis to achieve a differentiation between Piperis Herba and Piperis Kadsurae Caulis in terms of antioxidant activity.…”

Section: Methodsmentioning

confidence: 99%

“…Markview enables peak extraction, peak comparison and isotope removal for multiple batches of data, and t -tests for common peaks for multiple batches to analyze differential compounds [ 10 ]. In this experiment, we focused on the antioxidant activity of both [ 11 ], choosing the more widely used DPPH and ABTS free radical scavenging assays for a preliminary comparison of the antioxidant activity of Piperis Herba and Piperis Kadsurae Caulis [ 12 ]. The above analytical methods were used in order to achieve a differential evaluation of the composition and efficacy of the multi-origin, multi-batch sources of Piperis Herba and Piperis Kadsurae Caulis.…”

Section: Introductionmentioning

confidence: 99%

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Rapid Analysis of Compounds from Piperis Herba and Piperis Kadsurae Caulis and Their Differences Using High-Resolution Liquid–Mass Spectrometry and Molecular Network Binding Antioxidant Activity

Shi,

Liao,

Liu

et al. 2024

Molecules

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There is a serious mixing of Piperis Herba and Piperis Kadsurae Caulis in various parts of China due to the similar traits of lianas, and there is a lack of systematic research on the compound and activity evaluation of the two. Likewise, the differences in compounds brought about by the distribution of origin also need to be investigated. In this study, high-resolution liquid–mass spectrometry (UPLC-Q-Zeno-TOF-MS/MS) was used to analyze samples of Piperis Herba from five origins and Piperis Kadsurae Caulis from five origins, with three batches collected from each origin. The compounds were identified based on precise molecular weights, secondary fragments, and an online database combined with node-to-node associations of the molecular network. The t-test was used to screen and analyze the differential compounds between the two. Finally, the preliminary evaluation of antioxidant activity of the two herbs was carried out using DPPH and ABTS free radical scavenging assays. The results showed that a total of 72 compounds were identified and deduced in the two Chinese medicines. These compounds included 54 amide alkaloids and 18 other compounds, such as flavonoid glycosides. The amide alkaloids among them were then classified, and the cleavage pathways in positive ion mode were summarized. Based on the p-value of the t-test, 32 differential compounds were screened out, and it was found that the compounds of Piperis Herba were richer and possessed a broader spectrum of antioxidant activity, thus realizing a multilevel distinction between Piperis Herba and Piperis Kadsurae Caulis. This study provides a preliminary reference for promoting standardization and comprehensive quality research of the resources of Piperis Herba using Piperis Kadsurae Caulis as a reference.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rapid Analysis of Compounds from Piperis Herba and Piperis Kadsurae Caulis and Their Differences Using High-Resolution Liquid–Mass Spectrometry and Molecular Network Binding Antioxidant Activity

Shi,

Liao,

Liu

et al. 2024

Molecules

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“…41 In another study, the amount of TPC in the parsley extract was found to be 40 mg per gram. 42 Papuc et al found that the TPC value was 14.87 ± 1.03 mg GAE/100 mL in parsley juice. 43 It is thought that the higher TPC production in our study may be due to different production conditions and the difference in the region where parsley is obtained.…”

Section: Total Bioactive Compounds and Radical Scavenging Abilitiesmentioning

confidence: 98%

Impact of Thermosonication Treatment on Parsley Juice: Particle Swarm Algorithm (PSO), Multiple Linear Regression (MLR), and Response Surface Methodology (RSM)

Dulger Altıner,

Yıkmış,

Şimşek

et al. 2024

ACS Omega

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“…Other authors have performed co-extractions to enhance a certain bioactivity, such Vázquez et al [14] who performed the simultaneous extraction of rosemary and spinach leaves to enhance the antioxidant activity. Recently, synergistic effects on the antioxidant activity of marjoram and rosemary co-extracts obtained via pressurized liquid extraction have been demonstrated in all the different proportions studied [15]. However, previous research on the co-extraction of different natural matrices rich in steroidal and triterpenoid saponins in order to obtain extracts enriched in both types of saponins simultaneously has not been found.…”

Section: Introductionmentioning

confidence: 99%

Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates

Cantero-Bahillo,

Navarro del Hierro,

de las Nieves Siles-Sánchez

et al. 2024

Foods

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Saponins, both steroidal and triterpenoid, exhibit distinct bioactivities. However, they are not commonly found together in natural sources; instead, sources tend to be rich in one type or another and mainly in the form of saponins rather than the sapogenin aglycones. Developing co-extracts containing both saponin or sapogenin types would be a strategy to harness their respective bioactivities, yielding multibioactive extracts. Therefore, this study evaluates the bioactivity (hypolipidemic, antioxidant, and anti-inflammatory activities) of co-extracts from fenugreek seeds (steroidal-rich saponins) and quinoa husk (triterpenoid-rich saponins), co-extracted at varying proportions, alongside their respective sapogenin-rich hydrolysates. Pancreatic lipase inhibition increased with fenugreek content in co-extracts, especially in sapogenin-rich variants. The latter substantially interfered with cholesterol bioaccessibility (90% vs. 15% in sapogenin-rich extracts). Saponin-rich co-extracts exhibited reduced cytokine release with increased fenugreek content, while sapogenin-rich counterparts showed greater reductions with higher quinoa husk content. Limited cellular antioxidant activities were observed in all extracts, with improved post-hydrolysis bioactivity. Therefore, simultaneous co-extraction of steroidal and triterpenoid sources, such as fenugreek and quinoa husk, as well as their subsequent hydrolysis, are innovative strategies for obtaining multibioactive natural extracts.

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Theoretical framework to evaluate antioxidant synergistic effects from the coextraction of marjoram, rosemary and parsley

Cited by 10 publications

References 38 publications

Rapid Analysis of Compounds from Piperis Herba and Piperis Kadsurae Caulis and Their Differences Using High-Resolution Liquid–Mass Spectrometry and Molecular Network Binding Antioxidant Activity

Rapid Analysis of Compounds from Piperis Herba and Piperis Kadsurae Caulis and Their Differences Using High-Resolution Liquid–Mass Spectrometry and Molecular Network Binding Antioxidant Activity

Impact of Thermosonication Treatment on Parsley Juice: Particle Swarm Algorithm (PSO), Multiple Linear Regression (MLR), and Response Surface Methodology (RSM)

Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates

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