Theoretical investigations on stability, sensitivity, energetic performance, and mechanical properties of CL-20/TNAD cocrystal explosive by molecular dynamics method
“…A co-crystal with a higher value of E bind will be more stable and may be more likely or easily formed. 53,54 Therefore, self-gelation promoted the transformation from RES–PIP CM into its co-crystal system in the dissolution process.…”
Co-amorphous and co-crystal systems are attractive crystal-engineering strategies for poorly soluble drugs. Intermolecular interactions between components play a key role in the formation of the two systems, making the exploration...
“…A co-crystal with a higher value of E bind will be more stable and may be more likely or easily formed. 53,54 Therefore, self-gelation promoted the transformation from RES–PIP CM into its co-crystal system in the dissolution process.…”
Co-amorphous and co-crystal systems are attractive crystal-engineering strategies for poorly soluble drugs. Intermolecular interactions between components play a key role in the formation of the two systems, making the exploration...
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