Theory and Application Progress of Long Bone Segmental Defect Reparation and Reconstruction

Abstract

Objective: To summarize domestic and foreign research on reparation and reconstruction progress for long bone segmental defects in recent years. Method: The first author applied computers to retrieve articles of PubMed database, Chinese Journal Full-text Database and VIP Database about long bone segmental defect reparation and reconstruction according to English search term; bone defect, long bone reconstruction, tissue engineering of bone, scaffolds, bone reconstruction, bone graft, bone tumor; tumor resection, musculoskeletal tumors, regeneration, autografts' and Chinese search term 'large segment, bone defect, bone tumor, soft tissue tumor, enbolc resetion, tissue engineering and bone graft' from January 1990 to December 2012. A total of 104 related articles were searched, and 52 related articles were included for further study. Results and conclusion: Traditional repair methods of long bone segmental defects include autogenous bone graft, allogeneic bone graft, bone lengthening, artificial prosthetic replacement, etc. Development of prosthesis suitable for children limb salvage demands and consistent with children growth characteristics becomes a challenge for children limb salvage. People develop prosthesis capable of constant lengthening in order to solve the problem, which is used in limb salvage reconstruction for children bone tumor, with progress of medical technology. Various artificial bones, especially gradually application of bone tissue engineering and gene treatment gene treatment in bone defect repair, will further improve the remediation effect of bone defects. It is future research direction.