Theranostic vitamin E TPGS micelles of transferrin conjugation for targeted co-delivery of docetaxel and ultra bright gold nanoclusters

Muthu, Madaswamy S; Kutty, Rajaletchumy Veloo; Luo, Zhentao; Xie, Jianping; Feng, Si‐Shen

doi:10.1016/j.biomaterials.2014.11.008

Cited by 178 publications

(102 citation statements)

References 46 publications

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“…One of the advantages of micelles as drug carriers is their size (10e100 nm) which is bigger than the free drug molecules (1 nm). Thus, the nanocarrier protects the drugs from the otherwise immediate renal clearance by increases the circulatory half-life of this drug and facilitates the delivery through the leaky vasculature in solid tumours [18,35,36]. Table S2 shows the zeta potential for all the micelles as being negatively charged on the surface of both the TPD and TPDC.…”

Section: Characterization Of Docetaxel-loaded Micelles and Did-loadedmentioning

confidence: 99%

In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer

Kutty¹,

Chia²,

Setyawati³

et al. 2015

Biomaterials

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Section: Characterization Of Docetaxel-loaded Micelles and Did-loadedmentioning

confidence: 99%

In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer

Kutty¹,

Chia²,

Setyawati³

et al. 2015

Biomaterials

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“…25 Briefly, 1 mL of acetonitrile was added to into 1 mL of micelle suspension leading to the rupture and DTX release from nanomicelles. The obtained dispersion was filtered through a 0.45 µm membrane before being injected into HPLC.…”

Section: Determination Of Drug Loading Capacity and Entrapment Efficimentioning

confidence: 99%

Effects of X-shaped reduction-sensitive amphiphilic block copolymer on drug delivery

Xiao¹,

Wang²

2015

IJN

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To study the effects of X-shaped amphiphilic block copolymers on delivery of docetaxel (DTX) and the reduction-sensitive property on drug release, a novel reduction-sensitive amphiphilic copolymer, (PLGA) 2 -SS-4-arm-PEG 2000 with a Gemini-like X-shape, was successfully synthesized. The formation of nanomicelles was proved with respect to the blue shift of the emission fluorescence as well as the fluorescent intensity increase of coumarin 6-loaded particles. The X-shaped polymers exhibited a smaller critical micelle concentration value and possessed higher micellar stability in comparison with those of linear ones. The size of X-shaped (PLGA) 2 -SS-4-arm-PEG 2000 polymer nanomicelles (XNMs) was much smaller than that of nanomicelles prepared with linear polymers. The reduction sensitivity of polymers was confirmed by the increase of micellar sizes as well as the in vitro drug release profile of DTX-loaded XNMs (DTX/XNMs). Cytotoxicity assays in vitro revealed that the blank XNMs were nontoxic against A2780 cells up to a concentration of 50 µg/mL, displaying good biocompatibility. DTX/XNMs were more toxic against A2780 cells than other formulations in both dose- and time-dependent manners. Cellular uptake assay displayed a higher intracellular drug delivery efficiency of XNMs than that of nanomicelles prepared with linear polymers. Besides, the promotion of tubulin polymerization induced by DTX was visualized by immunofluorescence analysis, and the acceleration of apoptotic process against A2780 cells was also imaged using a fluorescent staining method. Therefore, this X-shaped reduction-sensitive (PLGA) 2 -SS-4-arm-PEG 2000 copolymer could effectively improve the micellar stability and significantly enhance the therapeutic efficacy of DTX by increasing the cellular uptake and selectively accelerating the drug release inside cancer cells.

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“…The IC50 results showed that the targeted and non-targeted micelles could be 71.73 and 15.31 folds more toxic than DTX after 24 hours presence in the MDA-MB-231-luc cells culture medium. Targeting transferrin receptors via theranostic micelles in xenograft model demonstrated potential of real-time tumor imaging and suppression of tumor growth [7].…”

Section: Nanoconjugated Ncs For Cancer Diagnosis and Therapymentioning

confidence: 99%

Gold Nanoclusters: Nanomedicine Potentials and Applications

Shahsavari¹,

Behroozi²

2016

JNMR

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Theranostic vitamin E TPGS micelles of transferrin conjugation for targeted co-delivery of docetaxel and ultra bright gold nanoclusters

Cited by 178 publications

References 46 publications

In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer

In vivo and ex vivo proofs of concept that cetuximab conjugated vitamin E TPGS micelles increases efficacy of delivered docetaxel against triple negative breast cancer

Effects of X-shaped reduction-sensitive amphiphilic block copolymer on drug delivery

Gold Nanoclusters: Nanomedicine Potentials and Applications

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