Theranostics: A Unique Concept to Nuclear Medicine

Mango, Lucio

doi:10.29328/journal.hjcsr.1001001

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…While nanotheranostic provide a concept of using one molecule for both diagnosis and therapy using nanoparticles, nuclear medicine uses radioactive nuclides to evaluate the distribution of radioactive molecules through the use of PET of SPECT systems to acquire images and diagnose diseases or evaluate response to treatments [5,6], and this is an especially applicable in the case of cancer diagnostic and therapy.…”

Section: Nanotheranostics and Nuclear Medicine: The Interrelationshipmentioning

confidence: 99%

Biomedical Applications of Targeted Drug Delivery, Nanotheranostic and Nuclear Medicine

Sadiq¹,

Fs²,

Ha³

2021

Preprint

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Background: Convectional methods for drug delivery often faces setbacks due to systemic distribution, short half-life and degradation of therapeutics and therefore reduce concentrations of drug available to target tissue. Nanotheranostic provide a novel method for treating and diagnosing diseases Methodology: collection and review of relevant literatureResult: while nanotheranostic offer advantage of personalized medicine and often combines diagnosis and therapy using single molecular approach, nuclear medicine relies on radioactive isotopes to diagnosed and destroys cancer cells. In both cases, nanocarriers such as lipid-based, polymer-based, drug-conjugate, inorganic nanoparticles are used to deliver drugs/probes/isotopes to target site, generating images and thereafter chemotherapy/radiotherapy begins.Conclusion: Nanotheranostic plays important role in diseases diagnostic, therapy, imaging, monitoring of disease progression / response through the use of nanocarriers. This is made possible through nanoparticles/nanocarriers that delivers drug to the target tissues/cells.

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Section: Nanotheranostics and Nuclear Medicine: The Interrelationshipmentioning

confidence: 99%

Biomedical Applications of Targeted Drug Delivery, Nanotheranostic and Nuclear Medicine

Sadiq¹,

Fs²,

Ha³

2021

Preprint

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“…This remarkable concept is named ‘theranostic’ ( Figure 1 ) [ 9 ]. This unique application (therapy + diagnostics) means combination of radiolabelled ligands with gamma-(γ) or positron-(β + ) emitting radionuclides for diagnostic purposes with the same ligand incorporating therapeutic radionuclides such as alpha-(α) or beta-(β − ) emitters to perform a personalised targeted treatment based on the preliminary diagnostic procedure [ 10 , 11 , 12 ]. Several successful theranostic approaches based on peptidomimetics, antibodies and small molecules have presented significant responses in clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Theranostic Advances in Breast Cancer in Nuclear Medicine

Vahidfar

Aghanejad

Ahmadzadehfar

et al. 2021

IJMS

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The implication of ‘theranostic’ refers to targeting an identical receptor for diagnostic and therapeutic purposes, by the same radioligand, simultaneously or separately. In regard to extensive efforts, many considerable theranostic tracers have been developed in recent years. Emerging evidence strongly demonstrates the tendency of nuclear medicine towards therapies based on a diagnosis. This review is focused on the examples of targeted radiopharmaceuticals for the imaging and therapy of breast cancer.

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“…Multifunctional nano- and microplatforms equipped with magnetic components, drugs, and diagnostic elements (or active shells) are of special interest [ 8 ]. For example, magnetic nanomaterials synthesized on the basis of hydroxyappatite Ca 10 (PO 4 ) 6 (OH) 2 (HAP) belong to this class of biological platforms since HAP is biologically active and is analogous to the inorganic component of bones [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

One-Step Synthesis of Magnetic Nanocomposite with Embedded Biologically Active Substance

et al. 2021

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Magnetic nanocomposites based on hydroxyapatite were prepared by a one-step process using the hydrothermal coprecipitation method to sinter iron oxides (Fe3O4 and γ-Fe2O3). The possibility of expanding the proposed technique for the synthesis of magnetic composite with embedded biologically active substance (BAS) of the 2-arylaminopyrimidine group was shown. The composition, morphology, structural features, and magnetic characteristics of the nanocomposites synthesized with and without BAS were studied. The introduction of BAS into the composite synthesis resulted in minor changes in the structural and physical properties. The specificity of the chemical bonds between BAS and the hydroxyapatite-magnetite core was revealed. The kinetics of the BAS release in a solution simulating the stomach environment was studied. The cytotoxicity of (HAP)FexOy and (HAP)FexOy + BAS composites was studied in vitro using the primary culture of human liver carcinoma cells HepG2. The synthesized magnetic composites with BAS have a high potential for use in the biomedical field, for example, as carriers for magnetically controlled drug delivery and materials for bone tissue engineering.

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Theranostics: A Unique Concept to Nuclear Medicine

Cited by 7 publications

References 17 publications

Biomedical Applications of Targeted Drug Delivery, Nanotheranostic and Nuclear Medicine

Biomedical Applications of Targeted Drug Delivery, Nanotheranostic and Nuclear Medicine

Theranostic Advances in Breast Cancer in Nuclear Medicine

One-Step Synthesis of Magnetic Nanocomposite with Embedded Biologically Active Substance

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