2024
DOI: 10.1007/s11010-024-05120-y
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Therapeutic applications and challenges in myostatin inhibition for enhanced skeletal muscle mass and functions

Brock Wetzlich,
Benard B. Nyakundi,
Jinzeng Yang

Abstract: Myostatin, a potent negative regulator of skeletal muscle mass, has garnered significant attention as a therapeutic target for muscle dystrophies. Despite extensive research and promising preclinical results, clinical trials targeting myostatin inhibition in muscle dystrophies have failed to yield substantial improvements in muscle function or fitness in patients. This review details the mechanisms behind myostatin’s function and the various inhibitors that have been tested preclinically and clinically. It als… Show more

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