Therapeutic Considerations and Conjugated Polymer‐Based Photosensitizers for Photodynamic Therapy

Meng, Zihui; Hou, Wenbo; Zhou, Hua; Zhou, Libo; Chen, Haobin; Wu, Changfeng

doi:10.1002/marc.201700614

Cited by 73 publications

(58 citation statements)

References 97 publications

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“…These cytotoxic species are the cause of biochemical effects causing oxidative damages, which will culminate in target cells' death [5]. Photodynamic therapy is distinguished by its minimal invasion and reduced damage to the surrounding healthy tissue compared to the most current therapies in cancer treatment, such as chemotherapy and radiotherapy [6].…”

Section: Introductionmentioning

confidence: 99%

Red and Near-Infrared Absorbing Dicyanomethylene Squaraine Cyanine Dyes: Photophysicochemical Properties and Anti-Tumor Photosensitizing Effects

et al. 2020

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Photodynamic therapy is a medical modality developed for the treatment of several diseases of oncological and non-oncological etiology that requires the presence of a photosensitizer, light and molecular oxygen, which combined will trigger physicochemical reactions responsible for reactive oxygen species production. Given the scarcity of photosensitizers that exhibit desirable characteristics for its potential application in this therapeutic strategy, the main aims of this work were the study of the photophysical and photochemical properties and the photobiological activity of several dicyanomethylene squaraine cyanine dyes. Thus, herein, the study of their aggregation character, photobleaching and singlet oxygen production ability, and the further application of the previously synthesized dyes in Caco-2 and HepG2 cancer cell lines, to evaluate their phototherapeutic effects, are described. Dicyanomethylene squaraine dyes exhibited moderate light-stability and, despite the low singlet oxygen quantum yields, were a core of dyes that exhibited relevant in vitro photodynamic activity, as there was an evident increase in the toxicity of some of the tested dyes exclusive to radiation treatments.

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Section: Introductionmentioning

confidence: 99%

Red and Near-Infrared Absorbing Dicyanomethylene Squaraine Cyanine Dyes: Photophysicochemical Properties and Anti-Tumor Photosensitizing Effects

et al. 2020

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“…Semiconducting polymer particles and nanoparticles with optical properties are of considerable importance for applications in a diverse range of technologies including light-emitting diodes (Wong, 2017), solar cells (Zhou et al, 2014; Jana et al, 2017), biosensing (Wu and Chiu, 2013; Chan and Wu, 2015; Xu et al, 2015), and cancer phototherapy (Li et al, 2018; Meng et al, 2018). Advantages of polymer particles include generally good optically stability, relatively routine preparation through emulsion polymerization or precipitation routes (Pecher and Mecking, 2010), and ready functionalization for different applications (Feng et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Size-Dependent Photophysical Behavior of Low Bandgap Semiconducting Polymer Particles

et al. 2019

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The photophysics of water and propan-1-ol suspensions of poly [N-9”-heptadecanyl-2,7-carbazole- alt −5,5-(4,7-di-2-thienyl-2′,1′,3′- benzothiadiazole)] (PCDTBT) nanoparticles and mesoparticles has been studied by ultrafast spectroscopy. High molar mass polymer (HMM > 20 kg/mol) forms nanoparticles with around 50 nm diameter via mini-emulsion post-polymerization, while low molar mass (LMM < 5 kg/mol) polymer prepared by dispersion polymerization results in particles with a diameter of almost one order of magnitude larger (450 ± 50 nm). In this study, the presence of excited-states and charge separated species was identified through UV pump and visible/near-infrared probe femtosecond transient absorption spectroscopy. A different behavior for the HMM nanoparticles has been identified compared to the LMM mesoparticles. The nanoparticles exhibit typical features of an energetically disordered conjugated polymer with a broad density of states, allowing for delayed spectral relaxation of excited states, while the mesoparticles show a J-aggregate-like behavior where interchain interactions are less efficient. Stimulated emission in the red-near infrared region has been found in the mesoparticles which indicates that they present a more energetically ordered system.

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“…PDT utilizes photosensitizer molecules (e.g., rose bengal) to convert normal oxygen ( 3 O 2 ) in the tissue to cytotoxic singlet oxygen ( 1 O 2 ) in the presence of light shining . The highly oxidative 1 O 2 can cause irreversible damage to many important biomolecules such as membrane lipids, proteins, and cellular DNA, and consequently kill the tumor cells. Considering the influence of illumination, the integrity of loaded pDNA must be guaranteed firstly to realize further combination therapy.…”

Section: Resultsmentioning

confidence: 99%

Flexible Cationic Nanoparticles with Photosensitizer Cores for Multifunctional Biomedical Applications

Wu¹,

Ding²,

Qi³

et al. 2018

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One challenge for multimodal therapy is to develop appropriate multifunctional agents to meet the requirements of potential applications. Photodynamic therapy (PDT) is proven to be an effective way to treat cancers. Diverse polycations, such as ethylenediamine-functionalized poly(glycidyl methacrylate) (PGED) with plentiful primary amines, secondary amines, and hydroxyl groups, demonstrate good gene transfection performances. Herein, a series of multifunctional cationic nanoparticles (PRP) consisting of photosensitizer cores and PGED shells are readily developed through simple dopamine-involving processes for versatile bioapplications. A series of experiments demonstrates that PRP nanoparticles are able to effectively mediate gene delivery in different cell lines. PRP nanoparticles are further validated to possess remarkable capability of combined PDT and gene therapy for complementary tumor treatment. In addition, because of their high dispersities in biological matrix, the PRP nanoparticles can also be used for in vitro and in vivo imaging with minimal aggregation-caused quenching. Therefore, such flexible nanoplatforms with photosensitizer cores and polycationic shells are very promising for multimodal tumor therapy with high efficacy.

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Therapeutic Considerations and Conjugated Polymer‐Based Photosensitizers for Photodynamic Therapy

Cited by 73 publications

References 97 publications

Red and Near-Infrared Absorbing Dicyanomethylene Squaraine Cyanine Dyes: Photophysicochemical Properties and Anti-Tumor Photosensitizing Effects

Red and Near-Infrared Absorbing Dicyanomethylene Squaraine Cyanine Dyes: Photophysicochemical Properties and Anti-Tumor Photosensitizing Effects

Size-Dependent Photophysical Behavior of Low Bandgap Semiconducting Polymer Particles

Flexible Cationic Nanoparticles with Photosensitizer Cores for Multifunctional Biomedical Applications

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