Therapeutic deep eutectic solvents based on natural product matrine and caprylic acid: Physical properties, cytotoxicity and formation of surfactant free microemulsion

Li, Menghan; Yuan, Jing; Yang, Qinghua; Liu, Zhuoni; Meng, Shengxi; Wang, Xiaoyong; Peng, Changjun; Yin, Tianxiang

doi:10.1016/j.jddst.2023.105177

Cited by 3 publications

(1 citation statement)

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“…Permeation behavior was explored by using the Franz diffusion method. A detailed description of the setup and the experimental process can be found in our previous publications. , Briefly, 4 mL solutions of artemisinin in DES, IPM, or emulsifier, DES-based microemulsion, and IPM-based microemulsion were put in the donor compartment, while 12 mL of a PBS solution with 30% PEG-400 was placed in the receptor compartment. A poly(ether sulfone) (PES) membrane (Sartorius, Germany) was set between these two compartments, which provided an effective transfer area of 1.37 cm 2 .…”

Section: Methodsmentioning

confidence: 99%

Multifunctional Deep Eutectic Solvent-Based Microemulsion for Transdermal Delivery of Artemisinin

Li,

Yuan,

Liu

et al. 2024

Langmuir

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As a serious public health issue, malaria threatens the health of millions of people. Artemisinin, a gift from traditional Chinese medicine, has been used in the treatment of malaria and has shown good therapeutic efficiency. However, due to its low solubility, poor bioavailability, and short half-life time, some smart delivery strategies are still required. Herein, a multifunctional DES prepared from ibuprofen and menthol was prepared. This DES was shown to efficiently promote the solubility of artemisinin up to 400-fold. Then, it was further applied as the oil phase to construct an O/W microemulsion with the help of Tween-80 + Span-20 mixed surfactants. The prepared microemulsion displayed high efficiency in improving the permeability of artemisinin, which can be ascribed to the presence of the permeation enhancer menthol in DES and the microstructure of the O/W microemulsion. Moreover, the simultaneous permeation of artemisinin and ibuprofen further indicated the potential benefits of the presented formulation in the treatment of malaria. To sum up, the microemulsion based on multifunctional DES presented herein provided an effective method for transdermal delivery of artemisinin.

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Section: Methodsmentioning

confidence: 99%

Multifunctional Deep Eutectic Solvent-Based Microemulsion for Transdermal Delivery of Artemisinin

Li,

Yuan,

Liu

et al. 2024

Langmuir

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Solubility and stability of curcuminoids in microemulsions formulated with hydrophobic and hydrophilic deep eutectic solvents and their in vitro anti-inflammatory effects

Yusakul,

Chunglok,

Warinhomhoun

et al. 2024

Journal of Drug Delivery Science and Technology

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Structure and Potential Application of Surfactant-Free Microemulsion Consisting of Heptanol, Ethanol and Water

Gudelj,

Kranjac,

Jurko

et al. 2024

Colloids and Interfaces

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Microemulsions, which are thermodynamically stable and isotropic mixtures of water, oil, and surfactants, attract significant research interest due to their unique physicochemical properties and diverse industrial applications. Traditional surfactant-based microemulsions (SBMEs) stabilize the interface between two typically immiscible liquids, forming various microstructures such as oil-in-water (O/W) droplets, water-in-oil (W/O) droplets, and bicontinuous phases. However, the use of surfactants poses environmental concerns, cost implications, and potential toxicity. Consequently, there is increasing interest in developing surfactant-free microemulsions (SFMEs) that offer similar benefits without the drawbacks associated with surfactants. In this study, we explore the formation and characteristics of a new surfactant-free microemulsion in a ternary system comprising water, ethanol, and heptanol. Advanced techniques are employed to characterize the microstructures and stability of surfactant-free microemulsions. These include electrical conductivity measurements, surface tension analysis, dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FTIR). These methods have been extensively used in previous research on surfactant-free microemulsions (SFMEs) to reveal the properties and interactions within microemulsion systems. The area of interest is identified using these techniques, where silica nanoparticles are subsequently synthesized and then visualized using transmission electron microscopy (TEM).

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Therapeutic deep eutectic solvents based on natural product matrine and caprylic acid: Physical properties, cytotoxicity and formation of surfactant free microemulsion

Cited by 3 publications

References 50 publications

Multifunctional Deep Eutectic Solvent-Based Microemulsion for Transdermal Delivery of Artemisinin

Multifunctional Deep Eutectic Solvent-Based Microemulsion for Transdermal Delivery of Artemisinin

Solubility and stability of curcuminoids in microemulsions formulated with hydrophobic and hydrophilic deep eutectic solvents and their in vitro anti-inflammatory effects

Structure and Potential Application of Surfactant-Free Microemulsion Consisting of Heptanol, Ethanol and Water

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