Therapeutic Effect of Toothpaste Containing Hydroxyapatite and Tribasic Calcium Phosphate on Dentinal Hypersensitivity

Abstract

Although it is not a pathological symptom, Dentinal Hypersensitivity (DH) describes pain felt by patients whose tooth roots are exposed outside of the gums and are therefore sensitive to external stimuli. DH is caused by tooth brushing or gum diseases and treatment to reduce the sensitivity can include use of materials having stimulation activity for DH or a resin material applied periodontally. This study examined the hypersensitivity treatment effects of a four-week treatment with a toothpaste containing hydroxyapatite and tricalcium phosphate (Hap-TCP toothpaste). The Hap-TCP toothpaste was made by mixing a commercially available fluorine-containing toothpaste with 10% (W/W) hydroxyapatite and 19% (W/W) tricalcium phosphate (both 99% purity based on XRD analysis). The tooth hypersensitivity treatment effect was surveyed by scoring VRS values, and showed no significant initial difference compared with the control. However, after 1 week of use, the pain reduction value was 8% in the treatment group compared to the control group. This value increased to 30% and 60% after 2 and 4 weeks, respectively. Hypersensitivity to cold stimulation, which was used as a VAS value, showed no initial significant differences compared with the control, but was significantly decreased after 1, 2, and 4 weeks in the experimental group, with more than a 3-fold difference after 4 weeks. These findings confirmed that remineralization can alleviate DH as hydroxyapatite fills dentinal tubules and calcium, phosphorus, and tricalcium phosphate ion equilibrium is established. [4,23,24,28]. 지각과민증 치료를 위한 여러 가지 방법 중에 약제를 첨가한 치약을 사용하는 것은 쉽고 가격이 비싸 지 않으며, 현실적으로 널리 이용될 수 있는 방법이다. 첨가약 제로 strontium chloride, potassium nitrate, sodium monofluoride phosphate (MFP), dibasic sodium citrate 등이 있다 [3, 5, 6, 4-17, 20, 22, 25]. Dibasic sodium citrate 겔, tricalcium phosphate (TCP), hydroxyapatite (HAp) 함유 치약의 경우에 도 지각과민증 완화효과가 우수하여 치약에 적용되고 있다.Hydroxyapatite 는 수용액에서 이온화상수가 매우 낮아 완전 한 중성의 인산칼슘으로서 화학식은 Ca10(PO4)6(OH)2이다. 인