2020
DOI: 10.1016/j.reth.2020.01.001
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Therapeutic effects and adaptive limits of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models

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Cited by 4 publications
(9 citation statements)
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“…Previous studies have reported the efficacy of UPAL gel implantation for cartilage tissue engineering. 2,12,14,22,25 Sukegawa et al 25 demonstrated that BM-MSCs can penetrate from the BM into a defect covered with UPAL gel. Igarashi et al 14 reported that UPAL gel enhances cell proliferation and chondrogenic differentiation of BM-MSCs and has a higher therapeutic efficacy for osteochondral defects than does commercial-grade alginate gel.…”
Section: Discussionmentioning
confidence: 99%
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“…Previous studies have reported the efficacy of UPAL gel implantation for cartilage tissue engineering. 2,12,14,22,25 Sukegawa et al 25 demonstrated that BM-MSCs can penetrate from the BM into a defect covered with UPAL gel. Igarashi et al 14 reported that UPAL gel enhances cell proliferation and chondrogenic differentiation of BM-MSCs and has a higher therapeutic efficacy for osteochondral defects than does commercial-grade alginate gel.…”
Section: Discussionmentioning
confidence: 99%
“…Using an acellular technique with UPAL gel, Baba et al 2 demonstrated that implantation of UPAL gel with BM stimulation techniques macroscopically and histologically improved cartilage repair for osteochondral defects compared with using BM stimulation techniques alone but exhibited no significant differences in subchondral bone and mechanical results. Onodera et al 22 compared the implantation of UPAL gel without cell transplantation between 2 osteochondral defects (diameters, 3.0 mm and 5.0 mm) in a canine model. Implantation of the UPAL gel without cell transplantation provided reparative tissues with hyaline-like cartilage for small defects; however, reparative tissues in large defects with UPAL gel were fibrocartilagenous.…”
Section: Discussionmentioning
confidence: 99%
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