Therapeutic function of a novel rat induced pluripotent stem cell line in a 6‑OHDA‑induced rat model of Parkinson's disease

Abstract

Parkinson's disease (Pd) is a progressive neurodegenerative movement disorder of the central nervous system that results from the loss of dopaminergic (dA) nigral neurons. Induced pluripotent stem cells (iPScs) have shown potential for cell transplantation treatment of neurodegenerative disorders. In the present study, the small molecules cHIR99021 and RepSox (CR) significantly facilitated reprogramming and enhanced the efficiency of GFP + /iPS-like colonies [rat iPScs induced by OcT3/4, Sox2, Klf4, c-Myc, Nanog and Lin28 + cR (RiPScs-6F/cR)] generation by ~4.