Therapeutic Implications of Differential Effects of New Phenothiazine Compounds

Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients

“…According to data from the 1960s which relate to FGA, 50% of cases manifest AIP within the first month of drug administration and 90% during the first 72 days (Ayd 1961). Other researchers observed that majority of patients develop AIP within 20 days (Freyhan 1959) while Medinar et al (1962) reported AIP within the first week of treatment. Improvement and recovery of AIP symptoms within 2 months was reported in two thirds of patients (Stephen and Williamson 1984).…”

Drug induced parkinsonism

“…DIP usually appears later than akathisia and dystonia after taking neuroleptics with 50 % of cases within the first 30 days and 90 % within 72 days [1]. But Freyhan reported that the majority of patients developed parkinsonian symptoms before the 20 th day [2], and Medinar found parkinsonism within the first week [3]. Patients treated with lower doses of neuroleptics or antiparkinsonian drugs improve over a period of 7-8 weeks, but some of the parkinsonian symptoms continue in 50 % of the patients with DIP despite anticholinergic drug treatment.…”

Patient- and Family-Identified Problems of Traumatic Brain Injury: Value and Utility of a Target Outcome Approach to Identifying the Worst Problems

“…16,[18][19][20] In a target outcome approach, patients (and/or their family caregivers) are asked an open-ended question about the most serious problem the condition causes. In Gitlin et al's studies, 18,19 participants also used a Likert-scaled response format to rate how difficult it was to manage that problem.…”