Therapeutic plasma exchange causing (not curing) hemolysis

Graham, Brendan C.; Burgstaler, Edwin A.; Winters, Jeffrey L.

doi:10.1002/jca.21596

Cited by 1 publication

(1 citation statement)

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“…27 Both PE and DPMAS can damage blood cells. 28 The findings of this study also showed that the combined application of PE and DPMAS had superimposed effects, which could be associated with blood cell damage caused by the separator and adsorption columns, as well as by the increased anticoagulation time induced by heparin.…”

Section: Discussionmentioning

confidence: 56%

Comparison of plasma exchange, double plasma molecular adsorption system, and their combination in treating acute-on-chronic liver failure

Guo

et al. 2020

J Int Med Res

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Objective Our objective was to compare the effectiveness of nonbiological artificial liver (NBAL) support, particularly short-term (28-day) survival rates, in patients who underwent treatment using double plasma molecular adsorption system (DPMAS), plasma exchange (PE), or combined PE+DPMAS, in addition to comprehensive physical treatment for different stages of acute-on-chronic liver failure (ACLF). Methods We retrospectively reviewed clinical data of 135 patients with ACLF who received NBAL treatment between November 2015 and February 2019. The patients were categorized into PE, DPMAS, and PE+DPMAS groups. Short-term effectiveness of treatment was assessed and compared based on selected clinical findings, laboratory parameters, and liver function markers. Results Coagulation function improved significantly in all groups after treatment. In the PE and PE+DPMAS groups, prothrombin time decreased to different degrees, whereas plasma thromboplastin antecedent increased significantly after treatment. White blood cell counts increased and platelet counts decreased in all groups after treatment. The model for end-stage liver disease score, Child–Pugh grade, systematic inflammatory syndrome score, and sepsis-related organ failure score decreased in all three groups after treatment. Conclusions PE, DPMAS, and PE+DPMAS improved disease indicators in all patients with ACLF. The combined treatment improved the short-term effectiveness of treatment, especially in patients with mild ACLF.

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Section: Discussionmentioning

confidence: 56%

Comparison of plasma exchange, double plasma molecular adsorption system, and their combination in treating acute-on-chronic liver failure

Guo

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

show abstract

Therapeutic plasma exchange causing (not curing) hemolysis

Cited by 1 publication

References 3 publications

Comparison of plasma exchange, double plasma molecular adsorption system, and their combination in treating acute-on-chronic liver failure

Comparison of plasma exchange, double plasma molecular adsorption system, and their combination in treating acute-on-chronic liver failure

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