Therapeutic plasma exchange for the treatment of thrombotic thrombocytopenic purpura: A retrospective multicenter study

Altuntaş, Fevzi; Aydogdu, Ismet; Kabukcu, Sibel; Koçyiğit, İsmail; Cikim, Kerim; Sarı, İsmail; Erkut, Murat; Eser, Bülent; Öztürk, Ahmet; Kaya, Emin; Çetın, Mustafa; Keskïn, Ali; Ünal, Ali

doi:10.1016/j.transci.2006.05.014

Cited by 38 publications

(32 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Within the 2 nd and 3 rd Days of treatment, platelet counts start to rise and serum LDH level begins to decline with improvement rate by 87.5 %. Altuntas et al [26], reported success rates at (77%). Also, Korkmaz et al [27], reported cure rate at (85-87%) in their study.…”

Section: Discussionmentioning

confidence: 98%

Outcomes of Therapeutic Plasma Exchange; One Year Single Center Experience

Ghonemy¹

2016

UNOAJ

View full text Add to dashboard Cite

Background: Outcome of therapeutic plasma exchange (TPE) in treating different immunological and non-immunological diseases in our unit is not clear. We aimed to study the outcome TPE in different diseases categories during one-year period.Methods: Prospective cross sectional study of patients referred for TPE during one year period. Demographic, clinical data, number of sessions, volume of plasma exchanged, patient tolerance and complications during or post to the procedure were systematically recorded and descriptive statistics applied for analysis.

show abstract

Section: Discussionmentioning

confidence: 98%

Outcomes of Therapeutic Plasma Exchange; One Year Single Center Experience

Ghonemy¹

2016

UNOAJ

View full text Add to dashboard Cite

show abstract

“…The coexistence of 5 symptoms, typical of TTP and often described in textbooks, is not frequent in clinical practice. It is clear from the series of cases that microangiopathic hemolytic anemia and thrombocytopenia occur in 100 % of patients and CNS symptoms in 60-88 % of cases, whereas renal function disorder (18-76 %) and fever (22-86 %) are less frequent [7].…”

Section: Discussionmentioning

confidence: 99%

Cryosupernatant and Immunosuppression as Effective Alternative Therapies for TTP in Three Pediatric SLE Patients

Palaniappan

Lionel

Agarwal

et al. 2014

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

Thrombotic thrombocytopenic purpura (TTP) and systemic lupus erythematosus (SLE) very rarely present simultaneously and pose a diagnostic and therapeutic dilemma to the physician. Prompt diagnosis and management with plasma exchange and immunosuppression is life-saving. To describe the effectiveness of cryosupernatant and steroids in pediatric SLE with TTP. We describe three children aged 12-14 years with SLE who were diagnosed with TTP based on fever, CNS manifestations, ANA, anti-dsDNA, anti-sm positivity, hypocomplementemia, and microangiopathic anemia with thrombocytopenia.

show abstract

“…Although TPE is undoubtedly efficacious, the choice of replacement fluid is still under discussion. FFP and CPP appear to be equally effective in the therapy of TTP [32][33][34]. Pooled SDP represents an alternative to single-donor FFP and CPP.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety Profile of Solvent/Detergent Plasma in the Treatment of Acute Thrombotic Thrombocytopenic Purpura: A Single-Center Experience

Edel

Al-Ali²,

Seeger³

et al. 2010

Transfus Med Hemother

View full text Add to dashboard Cite

Background: Thrombotic thrombocytopenic purpura (TTP) is a rare clinical disorder which was associated with poor prognosis for a long time. The outcome has been improved by the consistent introduction of thera-peutic plasma exchange (TPE) as standard treatment of TTP. Patients and Methods: We describe our experience in the use of solvent/detergent-treated plasma (SDP) for TPE in TTP. We retrospectively analyzed acute TTP epi-sodes in 8 patients (mean age = 27 years, range 18–44 years) treated with TPE using SDP with regard to tolerability and efficacy. Results: All 8 patients were positive for anti-ADAMTS-13 antibody. Seven out of 8 had a se-vere ADAMTS-13 deficiency. All patients responded rapidly to SDP TPE with an increase in platelet count to above 150 × 10⁹/l. Hemolytic anemia disappeared over the treatment period. Approximately 2,000 l SDP were used for more than 500 treatments. Treatment with SDP was well tolerated; none of the patients experienced an adverse drug reaction after exposure to SDP. No major complications occurred even after multiple TPE. Conclusion: Our investigations suggest that TPE using SDP as replacement fluid is an effective treatment for TTP. The data described also indicate that SDP might offer the benefit of reducing adverse drug reactions.

show abstract

Therapeutic plasma exchange for the treatment of thrombotic thrombocytopenic purpura: A retrospective multicenter study

Cited by 38 publications

References 54 publications

Outcomes of Therapeutic Plasma Exchange; One Year Single Center Experience

Outcomes of Therapeutic Plasma Exchange; One Year Single Center Experience

Cryosupernatant and Immunosuppression as Effective Alternative Therapies for TTP in Three Pediatric SLE Patients

Efficacy and Safety Profile of Solvent/Detergent Plasma in the Treatment of Acute Thrombotic Thrombocytopenic Purpura: A Single-Center Experience

Contact Info

Product

Resources

About