Therapeutic Potential and Molecular Targets of Piceatannol in Chronic Diseases

Surh, Young‐Joon; Na, Hye-Kyung

doi:10.1007/978-3-319-41334-1_9

Cited by 28 publications

(16 citation statements)

References 94 publications

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“…Another example is the stilbenoid piceatannol (found, e.g., in passion fruit seeds), an analog of resveratrol, which-along with its metabolite isorhapontigenin-was shown to stimulate SIRT1, activate autophagy (synergistically with resveratrol), deacetylate cytosolic proteins, improve parameters of metabolic syndrome in obese mice, promote murine astrocyte differentiation in vivo, and extend the lifespan of worms (Pietrocola et al, 2012;Surh and Na, 2016). However, to our knowledge, lifespan and healthspan data of piceatannol in higher models are elusive.…”

Section: Resveratrol and Other Sirt1 Activatorsmentioning

confidence: 99%

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

et al. 2019

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Section: Resveratrol and Other Sirt1 Activatorsmentioning

confidence: 99%

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

et al. 2019

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“…Piceatannol (PIC) is a polyphenolic stilbene found naturally in various plants, including grapes, rhubarb and sugarcane [13,14]. Pharmacological effects of PIC such as antioxidative, anti-inflammatory, anti-cancer and cardioprotective properties have been reported before [15].…”

Section: Introductionmentioning

confidence: 99%

Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts

Yan

Liu

et al. 2019

R. Soc. open sci.

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Osteoclasts are multinuclear giant cells that have unique ability to degrade bone. The search for new medicines that modulate the formation and function of osteoclasts is a potential approach for treating osteoclast-related bone diseases. Piceatannol (PIC) is a natural organic polyphenolic stilbene compound found in diverse plants with a strong antioxidant and anti-inflammatory effect. However, the effect of PIC on bone health has not been scrutinized systematically. In this study, we used RAW264.7, an osteoclast lineage of cells of murine macrophages, to investigate the effects and the underlying mechanisms of PIC on osteoclasts. Here, we demonstrated that PIC treatment ranging from 0 to 40 µM strongly inhibited osteoclast formation and bone resorption in a dose-dependent manner. Furthermore, the inhibitory effect of PIC was accompanied by the decrease of osteoclast-specific genes. At the molecular level, PIC suppressed the phosphorylation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK1/2), NF-κB p65, IκBα and AKT. Besides, PIC promoted the apoptosis of mature osteoclasts by inducing caspase-3 expression. In conclusion, our results suggested that PIC inhibited RANKL-induced osteoclastogenesis and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promoted caspase3-mediated apoptosis of mature osteoclasts, which might contribute to the treatment of bone diseases characterized by excessive bone resorption.

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“…9 Although reviews of piceatannol's role in cancer, CVD, and other chronic diseases have been conducted, the literature regarding its effect in metabolic disorders is limited. [10][11][12][13] This review will focus on the biological role of piceatannol in metabolic disorders. We conclude that although in vivo and human studies of piceatannol are currently insufficient to recommend its clinical use, the effect of piceatannol in modulating energy metabolism and inflammation merits further investigation of its use in the treatment and prevention of metabolic disease.…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review

Kershaw

Kim

2017

Journal of Medicinal Food

101

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Metabolic disease comprises a set of risk factors highly associated with obesity and insulin resistance and is a consequence of central adiposity, hyperglycemia, and dyslipidemia. Furthermore, obesity increases the risk of the development of metabolic disease due to ectopic fat deposition, low-grade inflammation, and systemic energy disorders caused by dysregulated adipose tissue function. Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and has been reported to exhibit anticancer and anti-inflammatory properties. In addition, recently reported beneficial effects of piceatannol on hypercholesterolemia, atherosclerosis, and angiogenesis underscore its therapeutic potential in cardiovascular disease. However, investigation of its role in metabolic disease is still in its infancy. This review intensively summarizes in vitro and in vivo studies supporting the potential therapeutic effects of piceatannol in metabolic disease, including inhibition of adipogenesis and lipid metabolism in adipocytes, and regulation of hyperlipidemia, hyperglycemia, insulin resistance, and fatty acid-induced inflammation and oxidative stress.

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Therapeutic Potential and Molecular Targets of Piceatannol in Chronic Diseases

Cited by 28 publications

References 94 publications

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts

The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review

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