Therapeutic Potential of Human Chorionic Gonadotropin Against Overactive Bladder

Abstract

Overactive bladder (OAB) is a common form of urinary incontinence, resulting from spontaneous and random contractions of the urinary bladder. The affected individuals have an uncontrollable urge to urinate and experience incontinence and nocturia, which can greatly reduce the quality of daily life. There are several drugs for the treatment, and all of them have serious side effects. The following findings suggested that human chorionic gonadotropin (hCG) has a therapeutic potential that is worth investigating for the treatment of OAB. The finding are (1) human detrusor muscle contains hCG receptors, (2) detrusor muscle becomes quiescent during pregnancy, (3) hCG can inhibit detrusor muscle contractions induced by cholinergic stimulation in rats, and (4) hCG can mimic the anticholinergic drug on detrusor muscle contractions.

Inclusion of Human Chorionic Gonadotropin in the Family of Therapeutic Glycoproteins

“…16,17 While living cell systems can make many of them, others can be made by glycoengineering. Some of them are already in clinical use, saving countless number of human lives.…”

“…16,17 Among the family members, four are selected for brief discussion to highlight their importance in the treatment of some of the most dreadful human diseases. The four are, erythropoietin (EPO), interferons (IFNs), monoclonal antibodies (mAbs) and tissue plasminogen activator (tPA).…”

Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells

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