Therapeutic range cromolyn dose-response inhibition and complete obliteration of SO-induced bronchoconstriction in atopic adolescents

Koenig, Jane Q.; Marshall, Susan G.; Belle, Gerald van; McManus, Michael S.; Bierman, C. Warren; Shapiro, Gail G.; Furukawa, Clifton T.; Pierson, William E.

doi:10.1016/0091-6749(88)90947-5

Cited by 25 publications

(2 citation statements)

References 30 publications

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“…44 SCG is also more effective than atropine in preventing the asthmatic response to sulphur dioxide which is mediated by atropine-sensitive mechanisms, probably through irritant airway receptors. 45 Long-term studies substantially confirmed the protective effect of SCG against allergen inhalation challenge (2-4 weeks of administration) 4 and cold air (4 weeks). 9 In exercise-induced bronchoconstriction, the drug effectiveness was unaffected by its chronic use (1 year).…”

Section: Sodium Cromoglycatementioning

confidence: 78%

Cromoglycate and Nedocromil: Influence on Airway Reactivity

Valletta

Boner

1994

Mediators of Inflammation

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Although basic mechanisms of bronchial hyper-responsiveness (BHR) are still incompletely understood, inflammation of airways is likely to play a fundamental role in modulating BHR in patients with asthma. The involvement of several inflammatory cells (eosinophils, mast cells, lymphocytes, neutrophils, macrophages and platelets) and of bioactive mediators secreted by these cells in the pathogenesis of asthma is well documented. Sodium cromoglycate and nedocromil sodium are two pharmacological agents which have anti-allergic and anti-inflammatory properties. Their clinical effectiveness in mild to moderate asthma, and the capacity to reduce BHR under different natural and experimental conditions, make them valuable drugs for maintenance therapy in patients with asthma.

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Section: Sodium Cromoglycatementioning

confidence: 78%

Cromoglycate and Nedocromil: Influence on Airway Reactivity

Valletta

Boner

1994

Mediators of Inflammation

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“…Sodium cromoglycate does not inhibit histamine-or methacholine-induced bronchoconstriction significantly [63] but attenuates bronchoconstriction induced by exercise, hyperosmolar challenges [64] and sulphur dioxide [65]. It prevents the allergen-induced early asthmatic response and inhibits [18] or delays [66] the onset of the late asthmatic response.…”

Section: Short-term Studiesmentioning

confidence: 99%

Therapy of bronchial hyper‐responsiveness

Magnussen

Rabe

Nowak

1991

Clin Experimental Allergy

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Bronchial responsiveness to inhaled metabisulfite in asthmatic children increases with age

Vandenbossche

Hop

Jongste

1993

Pediatric Pulmonology

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Inhaled bisulfite (HSO3) aerosol produces bronchoconstriction in asthmatics but not in normals. This effect is probably due to local formation of SO2 which stimulates vagal afferents in the airway mucosa, and gives rise to bronchoconstriction that is partly due to a cholinergic reflex. Metabisulfite (MBS) produces bronchoconstriction in most adult asthmatics, but its effect in children has received little attention. The present study was done to assess MBS-induced bronchoconstriction as a function of age in asthmatic children, and to compare MBS responsiveness with the response to inhaled metacholine (MCH), which is commonly used for bronchoprovocation testing. In 36 children with moderate asthma, selected to cover the age range between 3 and 20 years, we compared airway responsiveness to MBS and MCH, expressed as the provocative dose that causes a 20% fall in baseline forced expiratory volume in 1 sec (FEV1, PD20). We also measured the PD20 to MBS after pretreatment with the anticholinergic ipratropiumbromide, to estimate the noncholinergic component of the response. After bronchial provocation with MCH, a PD20 was reached in 32 children, and no significant relation of PD20 to age was found. A PD20[MBS] was seen in only 17 patients, and more frequently in older children. There was a significant negative correlation between age and PD20[MBS]. Ipratropium pretreatment reduced the response to MBS in 14 of the 17 children who had a PD20[MBS]. The PD20[MBS] after ipratropium pretreatment was also significantly negatively related with age. This suggested that the increased prevalence of MBS responsiveness was due to an increase of the noncholinergic component of the response.(ABSTRACT TRUNCATED AT 250 WORDS)

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Therapeutic range cromolyn dose-response inhibition and complete obliteration of SO-induced bronchoconstriction in atopic adolescents

Cited by 25 publications

References 30 publications

Cromoglycate and Nedocromil: Influence on Airway Reactivity

Cromoglycate and Nedocromil: Influence on Airway Reactivity

Therapy of bronchial hyper‐responsiveness

Bronchial responsiveness to inhaled metabisulfite in asthmatic children increases with age

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