Therapeutic response to sulpiride in the treatment of schizophrenia

Abstract

Schizophrenia. antipsychotics and neuroimaging 421s outside of 2 standard deviations were considered abnormal. In contrastto a group of 61 age-matched normal controls. Vmean in MCA and ACA was significantly increased in the schizophrenic group on admission (p < 0.05). PI was not significantly changed in any of the ultrasounded vessels.Vmeanshoweda significant positivecorrelation to the degreeof positivesymptomatology in PANSS(p < 0.05). After psychopathological improvement, a significant decrease of Vmean was found(p < 0.05). First results indicate a correlation between the increased blood flowvelocity found inTCD and brain SPECTresults. Thus. increased Vmean in frontal brain circulation may be seen as an indication of increased perfusion (SPECT), which correlates positively with the degree of productive schizophrenic symptomatology. Further study will show ifTCD may be used routinelyto add to. or even substitute. SPECTor PET examinations, thus constitutingan alternative method to radionuclides.