Therapeutic Role of Functional Components in Alliums for Preventive Chronic Disease in Human Being

Abstract

Objectives. Functional components in alliums have long been maintained to play a key role in modifying the major risk factors for chronic disease. To obtain a better understanding of alliums for chronic disease prevention, we conducted a systematic review for risk factors and prevention strategies for chronic disease of functional components in alliums, based on a comprehensive English literature search that was conducted using various electronic search databases, especially the PubMed, ISI Web of Science, and CNKI for the period 2007–2016. Allium genus especially garlic, onion, and Chinese chive is rich in organosulfur compounds, quercetin, flavonoids, saponins, and others, which have anticancer, preventive cardiovascular and heart diseases, anti-inflammation, antiobesity, antidiabetes, antioxidants, antimicrobial activity, neuroprotective and immunological effects, and so on. These results support Allium genus; garlic and onion especially may be the promising dietotherapeutic vegetables and organopolysulfides as well as quercetin mechanism in the treatment of chronic diseases. This review may be used as scientific basis for the development of functional food, nutraceuticals, and alternative drugs to improve the chronic diseases.

Allium vegetables for possible future of cancer treatment

“…The garlic's protective effects are mainly due to the presence of OSCs (Le Bon & Siess, ; H. Suleria, Khalid, et al, ). S‐allyl, S‐methyl, and S‐ethyl derivatives of cysteine along with alliin (C 6 H 11 NO 3 S) are of the most vital OSCs that their apoptotic, radical scavenging (antioxidant) activity, and antiinflammatory effects were proven (Zeng et al, ; Bisen & Emerald, ). As free radicals and inflammation are closely linked to cancer development, many compounds used as antioxidant and/or antiinflammatory can be used to treat cancers (Kumari, Badana, & Malla, ; Leo, Ortega, & Campos, ).…”

“…Many mechanisms proposed for anticancer activity of A . cepa included inhibition of protein tyrosine kinases and cell proliferation, blocking of carcinogens activation, and modulation of phase II detoxifying enzymes (Abdelrahman et al, ; Sengupta, Ghosh, & Bhattacharjee, ; Zeng et al, ). Evaluating the anticancer effects of A .…”

“…Allium plants contain powerful antioxidants, sulfur, and numerous phenolic compounds that have attracted much attention in the food industry (Beretta et al, ; Sultan, Buttxs, Qayyum, & Suleria, ). For many years, they have been used to prevent and treat certain diseases such as diabetes, arthritis, colds and flu, cough, headache, hemorrhage, asthma, atherosclerosis, and inflammatory diseases (H. A. R. Suleria, Butt, Khalid, et al, ; Suleria, Butt, Anjum, Arshad, & Khalid, ; Zeng et al, ). It has recently been noted that these vegetables, in addition to the conventional antibacterial, antifungal, antiviral, antiprotozoal, and antiworm effects, showed extensive in vitro and in vivo antiproliferative, antimotility, and cytotoxic potentials against cancer cells (Abdelrahman, Mahmoud, El‐Sayed, Tanaka, & Tran, ; Chu et al, ; Kazemi, Zolfaghari, Keivanloo Shahrestanaki, & Sadeghi Dinani, ; Kocić‐Tanackov et al, ; Packia Lekshmi, Viveka, Jeeva, & Raja Brindha, ; Sharifi‐Rad et al, ).…”

Prospects of application of the complex with artichoke and garlic in clinical medicine

“…Він входить у число трьох найбільш уживаних серед 491 видів харчових добавок рослинного походження у країнах ЄС [4]. Не менш відома і тривала історія медичного ви-користання часнику (Allium sativum), що також останніми роками все частіше застосовується у сучасній клінічній медицині, демонструючи бага-тогранний позитивний вплив на організм [5,6]. Практичний та науковий інтерес представляє їх використання у комплексі.…”

“…За думкою дослідників цільовою групою паці-єнтів для ПРП з часнику є пацієнти з метабо-лічним синдромом, для яких разом із гіполіпі-демічними властивостями будуть корисними і гіпотензивні ефекти препарату. В останніх мета-аналізах підтверджується потенціал ПРП, зокре-ма часнику, щодо корекції та лікування дислі-підемій [5,30]. Незважаючи на те, що за ефек-том часник не перевищує статини, він цікавий через свій значно вищий профіль безпеки [31].…”