Therapeutic Window Beyond Cerebral Ischemic Reperfusion Injury

Yu, Wengui; Liu, Liping

doi:10.1007/978-3-319-90194-7_16

Cited by 5 publications

(11 citation statements)

References 63 publications

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“…Reperfusion injury occurring in consequence of ischemic stroke is an intricate process involving several processes. Also, thrombolytic therapy itself can lead to brain injuries, named cerebral ischemia/reperfusion (I/R) injury 7,8 . I/R injury is one of the major reasons for disability, high morbidity, and mortality worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…Also, thrombolytic therapy itself can lead to brain injuries, named cerebral ischemia/reperfusion (I/R) injury. 7,8 I/R injury is one of the major reasons for disability, high morbidity, and mortality worldwide. Due to the lack of effective neuroprotective treatments, the care for I/R injury continues to be a main medical concern and needs to be thoroughly investigated.…”

Section: Introductionmentioning

confidence: 99%

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Neuroprotective effects of human amniotic fluid stem cells-derived secretome in an ischemia/reperfusion model

Castelli

Antonucci

Tessitore

et al. 2020

Stem Cells Translational Medicine

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Stem cells offer the basis for the promotion of robust new therapeutic approaches for a variety of human disorders. There are still many limitations to be overcome before clinical therapeutic application, including a better understanding of the mechanism by which stem cell therapies may lead to enhanced recovery. In vitro investigations are necessary to dissect the mechanisms involved and to support the potential development in stem cell-based therapies. In spite of growing interest in human amniotic fluid stem cells, not much is known about the characteristics of their secretome and regarding the potential neuroprotective mechanism in different pathologies, including stroke. To get more insight on amniotic fluid cells therapeutic potential, signal transduction pathways activated by human amniotic fluid stem cells (hAFSCs)derived secretome in a stroke in vitro model (ischemia/reperfusion [I/R] model) were investigated by Western blot. Moreover, miRNA expression in the exosomal fraction of the conditioned medium was analyzed. hAFSCs-derived secretome was able to activate prosurvival and anti-apoptotic pathways. MicroRNA analysis in the exosomal component revealed a panel of 16 overexpressed miRNAs involved in the regulation of coherent signaling pathways. In particular, the pathways of relevance in ischemia/reperfusion, such as neurotrophin signaling, and those related to neuroprotection and neuronal cell death, were analyzed. The results obtained strongly point toward the neuroprotective effects of the hAFSCs-conditioned medium in the in vitro stroke model here analyzed. This can be achieved by the modulation and activation of pro-survival processes, at least in part, due to the activity of secreted miRNAs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of human amniotic fluid stem cells-derived secretome in an ischemia/reperfusion model

Castelli

Antonucci

Tessitore

et al. 2020

Stem Cells Translational Medicine

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“…Acute LVO may lead to significant reduction of cerebral blood flow (CBF), resulting in a small irreversible infarct core and surrounding area of ischemic tissue that may be salvaged with prompt reperfusion (ischemic penumbra) (56, 57). Without reperfusion, the infarct core can expand and reach the size of the ischemic penumbra depending on duration of LVO and collaterals (56, 57).…”

Section: Introductionmentioning

confidence: 99%

“…The periprocedural sICH is the most feared complication of EVT (13–22, 57). Early pathophysiological responses to sudden LVO are distal vasodilation to compensate for dramatic reduction in tissue perfusion and subsequent loss of vascular reactivity.…”

Section: Introductionmentioning

confidence: 99%

“…Early pathophysiological responses to sudden LVO are distal vasodilation to compensate for dramatic reduction in tissue perfusion and subsequent loss of vascular reactivity. Reperfusion leads to blood overflow into the dilated vasculature, resulting in hyperperfusion, cerebral edema, capillary leak, or hemorrhage (57, 79). Endothelial cell injury and impairment of the blood-brain barrier (BBB) are likely the underlying mechanism of ICH (79).…”

Section: Introductionmentioning

confidence: 99%

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A Simple Imaging Guide for Endovascular Thrombectomy in Acute Ischemic Stroke: From Time Window to Perfusion Mismatch and Beyond

Jiang²

2019

Front. Neurol.

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Comparative Studies of Cerebral Reperfusion Injury in the Posterior and Anterior Circulations After Mechanical Thrombectomy

Bower

Suzuki

Golshani

et al. 2022

Transl. Stroke Res.

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Cerebral reperfusion injury is the major complication of mechanical thrombectomy (MT) for acute ischemic stroke (AIS). Contrast extravasation (CE) and intracranial hemorrhage (ICH) are the key radiographical features of cerebral reperfusion injury. The aim of this study was to investigate CE and ICH after MT in the anterior and posterior circulation, and their effect on functional outcome. This is a retrospective study of all consecutive patients who were treated with MT for AIS at University of California Irvine Medical Center between January 1, 2014, and December 31, 2017. Patient characteristics, clinical features, procedural variables, contrast extravasation, ICH, and outcomes after MT were analyzed. A total of 131 patients with anterior circulation (AC) stroke and 25 patients with posterior circulation (PC) stroke underwent MT during the study period. There was no statistically significant difference in admission NIHSS score, blood pressure, rate of receiving intravenous tPA, procedural variables, contrast extravasation, and symptomatic ICH between the 2 groups. Patients with PC stroke had a similar rate of favorable outcome (mRS 0–2) but significantly higher mortality (40.0% vs. 10.7%, p < 0.01) than patients with AC stroke. Multivariate regression analysis identified initial NIHSS score (OR 1.1, CI 1.0–1.2, p = 0.01), number of passes with stent retriever (OR 2.1, CI 1.3–3.6, p < 0.01), and PC stroke (OR 9.3, CI 2.5–35.1, p < 0.01) as independent risk factors for death. There was no significant difference in functional outcomes between patients with and without evidence of cerebral reperfusion injury after MT. We demonstrated that AC and PC stroke had similar rates of cerebral reperfusion injury and favorable outcome after MT. Cerebral reperfusion injury is not a significant independent risk factor for poor functional outcome.

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Therapeutic Window Beyond Cerebral Ischemic Reperfusion Injury

Cited by 5 publications

References 63 publications

Neuroprotective effects of human amniotic fluid stem cells-derived secretome in an ischemia/reperfusion model

Neuroprotective effects of human amniotic fluid stem cells-derived secretome in an ischemia/reperfusion model

A Simple Imaging Guide for Endovascular Thrombectomy in Acute Ischemic Stroke: From Time Window to Perfusion Mismatch and Beyond

Comparative Studies of Cerebral Reperfusion Injury in the Posterior and Anterior Circulations After Mechanical Thrombectomy

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