Therapy-induced bone changes in oncology imaging with 18F-sodium fluoride (NaF) PET–CT

Ahmed, Najeeb; Sadeq, Alyaa; Marafi, Fahad; Gnanasegaran, Gopinath; Usmani, Sharjeel

doi:10.1007/s12149-022-01730-y

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…Of note, it should be highlighted that patients with previous external beam treatment on bone metastatic lesions were not enrolled in this study. Radiation therapy determines bone hypoxia, hypocellularity and the reduction of vascularization bringing down the osteoblastic and osteoclastic metabolisms [34]. All these effects, taken together, may lead to a decrease in radiopharmaceuticals bone uptake including 18 F-NaF.…”

Section: Discussionmentioning

confidence: 99%

Tumor Burden of Iodine-Avid Bone Metastatic Thyroid Cancer Identified via 18F-Sodium Fluoride PET/CT Imaging

Nappi,

Zampella,

Gaudieri

et al. 2024

JCM

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Background: Patients with differentiated thyroid cancer (DTC) are referred to radioactive 131I (RAI) therapy and post-therapy 131I whole-body scintigraphy (WBS) to identify local and/or remote metastases. Positron emission tomography (PET)/computed tomography (CT) imaging with 18F-fluoro-D-glucose (FDG) or 18F-sodium fluoride (NaF) may also be used with these patients for the evaluation of bone metastases. We compared the role of 18F-NaF PET/CT and 18F-FDG-PET/CT in patients with DTC and documented bone metastases at post-therapy WBS. Methods: Ten consecutive DTC patients with iodine avid bone metastasis at post-therapy WBS referred to 18F-NaF PET/CT and 18F-FDG PET/CT were studied. The findings of the three imaging procedures were compared for abnormal detection rates and concordance. Results: At post-therapy 131I WBS, all patients had skeletal involvement with a total of 21 bone iodine avid lesions. At 18F-FDG PET/TC, 19 bone lesions demonstrated increased tracer uptake and CT pathological alterations, while 2 lesions did not show any pathological finding. At 18F-NaF PET/CT, the 19 bone lesions detected at 18F-FDG PET/TC also demonstrated abnormal tracer uptake, and the other 2 bone iodine avid foci did not show any pathological finding. Conclusions: In patients with DTC, 18F-NaF PET/CT did not obtain more information on the metastatic skeletal involvement than post-therapy 131I WBS and 18F-FDG PET/CT.

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Section: Discussionmentioning

confidence: 99%