Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis

Lima, Antônio Fernando Martorelli de; Cury, Cmila Cristina; Palioto, Daniela Bazan; Duro, Adhemar Mendes; Silva, Robert Carvalho da; Wolff, Larry F.

doi:10.1111/j.0303-6979.2004.00576.x

Cited by 40 publications

(35 citation statements)

References 49 publications

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“…Poor glycaemic control can increase the incidence and accelerate the progression of periodontal disease [114,116,117], while, in the presence of periodontal infection, glycaemic control can worsen [119]. Good oral hygiene remains an essential component of diabetes care but the addition of a tetracycline may provide additional benefit in type 1 patients with periodontal defects [120].…”

Section: Periodontal Diseasementioning

confidence: 99%

Common infections in diabetes: pathogenesis, management and relationship to glycaemic control

Peleg

Weerarathna

McCarthy

et al. 2006

Diabetes Metabolism Res

506

406

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SummarySpecific defects in innate and adaptive immune function have been identified in diabetic patients in a range of in vitro studies. However, the relevance of these findings to the integrated response to infection in vivo remains unclear, especially in patients with good glycaemic control. Vaccine efficacy seems adequate in most diabetic patients, but those with type 1 diabetes and high glycosylated haemoglobin levels are most likely to exhibit hyporesponsiveness. While particular infections are closely associated with diabetes, this is usually in the context of extreme metabolic disturbances such as ketoacidosis. The link between glycaemic control and the risk of common community-acquired infections is less well established but could be clarified if infection data from large community-based observational or intervention studies were available. The relationship between hospital-acquired infections and diabetes is well recognized, particularly among post-operative cardiac and critically ill surgical patients in whom intensive insulin therapy improves clinical outcome independent of glycaemia. Nevertheless, further research is needed to improve our understanding of the role of diabetes and glycaemic control in the pathogenesis and management of community-and hospitalacquired infections.

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Section: Periodontal Diseasementioning

confidence: 99%

Common infections in diabetes: pathogenesis, management and relationship to glycaemic control

Peleg

Weerarathna

McCarthy

et al. 2006

Diabetes Metabolism Res

506

406

View full text Add to dashboard Cite

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“…Local administration of antibacterial agent was considered to be effective in the treatment of periodontal diseases under diabetic condition 51,52) . Consequently oral care and early treatment considering food impaction, biological state of the gingival col would be required to maintain and improve oral health at diabetic patients.…”

Section: The Measurement Of Osteoclastsmentioning

confidence: 99%

Disturbance of Periodontal Tissue Caused by Mechanical Compression into the Gingival Col of Streptozotocin-induced Diabetic Rats

Tokunaga

Enoki

Okamura

et al. 2014

J. Hard Tissue Biology.

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FThe purpose of this study is to clarify the destructive processes of periodontal tissue, especially of alveolar bone, induced by food impaction. Streptozotocin-induced diabetic rat was used, gutter percha point (GP) was inserted into interdental gingival col space between upper M1 and M2, and the change of body weight, histopathological findings and 3D SEM structure of alveolar bone were compared between diabetic (Group DM) and control (Group N) animals (Experiment 1). Large amounts of bacterial deposits and sequester were observed at the alveolar crest, and subsequently experiment 2 was carried out to explore the relationship between bacterial infection and sequester formation. The combination of mechanical compression and daily twice cleaning with 3% oxydol and Periocline were carried out. As a result of experiment 1, ulceration with partial exposure of alveolar crest, inflammatory infiltrates and hyaline degeneration occurred in the col, and bone resorption was scarcely observed at 1d in Group N. Bone resorption of alveolar bone progressed at 3d and 5d, decreasing the height of alveolar crest and the width of alveolar bone. Reepithelization of ulcer surface was observed at 7d and 14d, and concurrently bone resorption regressed and new bone formation suggested reparative changes. SEM observation confirmed these changes of alveolar bone. On the contrary, massive bacterial deposits were observed, and bone resorption was scanty in the upper region and slight in the middle to lower region of alveolar bone at 1 day of Group DM. Massive bacterial deposits with partial exposure of alveolar bone were observed at 3d and 5d, and sequester was isolated owing to intense undermining bone resorption. Regeneration of epithelium was seen beneath the sequester at 14d, showing the phenomenon of foreign body exclusion. The light microscopic changes of Group DM were consistent with SEM findings. The total number of osteoclasts was fewer at 1d and larger at 3d and 5d in Group DM. Osteoclasts at the upper region of alveolar bone increased from 1d to 5d in Group N, although the number of osteoclasts did not show a significant change in Group DM. At the middle to lower portion of alveolar bone, the number of osteoclast was significantly fewer at 1d, larger at 3d and 5d in Group DM. In experiment 2, the col with ulceration and necrosis did not show bacterial deposits or sequester, suggesting the intimate relation between bacterial infection and sequestration. The present study suggests that food impaction and subsequent mechanical compression to the col could induce various damages of periodontal tissue, including sequester formation, and elaborate plaque control at the initial stage of food impaction could prevent sequester formation and protect the height of alveolar bone.

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“…MH, an antibiotic, is a tetracycline derivative and has been used for decades in humans to treat a variety of infectious diseases, such as periodontitis [35], bedsores and burn wounds [36]. The drug also has neuroprotective effects distinct from its antimicrobial effect in several neurological disorders, including ischemic brain injury [37].…”

Section: Solubilization Of Mh In Oqcmc Micellesmentioning

confidence: 99%

Novel Quaternized Chitosan and Polymeric Micelles With Cross-Linked Ionic Cores for Prolonged Release of Minocycline

Liang

Tian

Luo

et al. 2009

Journal of Biomaterials Science, Polymer Edition

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Novel multifunctional octadecyl quaternized carboxymethyl chitosans (OQCMCs) with varying degree of quaternary substitution (DS) and molecular mass were prepared and compared with quaternized chitosan. OQCMCs exhibited excellent solubility both in water and organic solvents. Nanoparticles of OQCMCs offered many advantages, such as easier fabrication and modulation of their size and degree of positive charge, and a lower cytotoxic effect compared with PEI (25 kDa). DNA can be successfully adsorbed on its surface. Electrostatic attraction of carboxymethyl and quaternary groups in OQCMCs was utilized as micellar template for the synthesis of cross-linked micelles. Formation and characteristics of OQCMC polymeric micelles were studied by fluorescence spectroscopy, tensiometry, SEM, TEM and particle size analysis. Self-assembled OQCMC micelles were evaluated as carrier of the lipophilic drug, minocycline hydrochloride (MH). MH was incorporated into cross-linked ionic cores of micelles with remarkably high efficiency (22.7%, w/w). MH-loaded OQCMC polymeric micelles exhibited a slow steady release profile over a 1-week period at 37 degrees C. The OQCMC micelles are potentially useful for gene and lipophilic drug delivery applications.

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Therapy with adjunctive doxycycline local delivery in patients with type 1 diabetes mellitus and periodontitis

Abstract: These findings suggest that subgingivally delivered doxycycline hyclate produces additional favorable clinical results to periodontal therapy in type 1 DM patients.

Cited by 40 publications

References 49 publications

Common infections in diabetes: pathogenesis, management and relationship to glycaemic control

Common infections in diabetes: pathogenesis, management and relationship to glycaemic control

Disturbance of Periodontal Tissue Caused by Mechanical Compression into the Gingival Col of Streptozotocin-induced Diabetic Rats

Novel Quaternized Chitosan and Polymeric Micelles With Cross-Linked Ionic Cores for Prolonged Release of Minocycline

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