2020
DOI: 10.3390/cells9071629
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Therapy with Cardiomyocytes Derived from Pluripotent Cells in Chronic Chagasic Cardiomyopathy

Abstract: Chagas disease discovered more than a century ago remains an incurable disease. The objective of this work was to investigate the therapeutic potential of cardiomyocytes derived from mouse embryonic stem cells (CM-mESC) in a model of chronic Chagasic cardiomyopathy (CCC). Mouse embryonic stem cells (mESC) were characterized, transduced with luciferase, and submitted to cardiac differentiation. CM-mESC were labeled with superparamagnetic iron oxide particles. To induce CCC, mice were infected with Brazi… Show more

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Cited by 3 publications
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“…Interestingly, tracer binding was reduced in mice receiving cell transplantation leading to enhanced regeneration. Another mouse model of cardiomyocyte transplantation from pluripotent embryonic stem cells was used for the treatment of chronic Chagas-cardiomyopathy by Brasil et al [ 7 ]. Cardiac recovery, however, was not induced by cardiomyocyte cell transplantation in chronic Chagas cardiomyopathy.…”
mentioning
confidence: 99%
“…Interestingly, tracer binding was reduced in mice receiving cell transplantation leading to enhanced regeneration. Another mouse model of cardiomyocyte transplantation from pluripotent embryonic stem cells was used for the treatment of chronic Chagas-cardiomyopathy by Brasil et al [ 7 ]. Cardiac recovery, however, was not induced by cardiomyocyte cell transplantation in chronic Chagas cardiomyopathy.…”
mentioning
confidence: 99%