There is more into ‘doing’ than ‘knowing’: The function of the right inferior frontal sulcus is specific for implementing versus memorising verbal instructions

Demanet, Jelle; Liefooghe, Baptist; Hartstra, Egbert; Wenke, Dorit; Houwer, Jan De; Braß, Marcel

doi:10.1016/j.neuroimage.2016.07.059

Cited by 35 publications

(54 citation statements)

References 39 publications

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“…The particular locus of activity reported in this study lay within the ventral portion of the inferior frontal junction (IFJ)-an area that has long received attention for its role in cognitive control and working memory (Brass, Derrfuss, Forstmann, & von Cramon, 2005;Derrfuss, Brass, & von Cramon, 2004). This departure from the more systematic findings of the right LPFC involvement in verbal instruction implementation (Putt et al, 2017;Demanet et al, 2016;Ruge & Wolfensteller, 2010) warrants a more targeted investigation into these regions' neural dynamics during instruction implementation versus memorization at various stages of training.…”

Section: Introductionmentioning

confidence: 76%

“…Of primary interest to this study is the activation cluster reported in Demanet et al (2016), which spanned from the middle aspects of the right frontal gyrus back to the dorsal premotor cortex (Figure 2, violet). Although this cluster was originally labeled by Demanet et al (2016) the IFS because of its observed peak coordinates (MNI, x = 39, y = 20, z = 31), its anatomical overlap and resemblance with the cluster reported earlier by Ruge and Wolfensteller (2010) as the rMFG-dPMC motivated us to choose the latter label for consistency. The ROI used for this cluster is the original cluster of activity observed by Demanet et al (2016).…”

Section: Regions Of Interestmentioning

confidence: 99%

“…Within the study of human cognitive and motor control, appreciable progress has been made in describing the connection between symbolic information integration and complex action learning, opening new lines of research on how verbal instructions influence the neural and cognitive correlates of human behavior (Meiran, Liefooghe, & De Houwer, 2017;Demanet et al, 2016;Meiran, Pereg, Kessler, Cole, & Braver, 2015;Everaert, Theeuwes, Liefooghe, & De Houwer, 2014;Liefooghe, De Houwer, & Wenke, 2013;Liefooghe, Wenke, & De Houwer, 2012;Ruge & Wolfensteller, 2010). In this respect, this study aims to expand upon recent findings on the role of the lateral prefrontal cortex (LPFC) in implementing and memorizing verbal instructions at different levels of information processing and training.…”

Section: Introductionmentioning

confidence: 99%

“…However, that study did not directly compare LPFC involvement in implementing versus memorizing verbal instructions. A more recent study by Demanet et al (2016) aimed to contrast brain activity during instruction encoding between participants asked to implement stimulus-response mappings on the one hand and participants tasked with memorizing these mappings on the other. Consistent with Ruge and Wolfensteller's (2010) findings, these authors reported a cluster of activity within the rMFG-dPMC in the implementation group only.…”

Section: Introductionmentioning

confidence: 99%

“…Our primary goal was to examine whether LPFC might exhibit sensitivity to novel instruction implementation versus memorization following similar neurocognitive patterns as observed in Demanet et al (2016). In addition, Hartstra et al's data set allowed for further investigations into how LPFC activity during instruction implementation versus memorization is modulated by training.…”

Section: Introductionmentioning

confidence: 99%

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Encoding of Novel Verbal Instructions for Prospective Action in the Lateral Prefrontal Cortex: Evidence from Univariate and Multivariate Functional Magnetic Resonance Imaging Analysis

Bourguignon

Braem

Hartstra

et al. 2018

Journal of Cognitive Neuroscience

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Abstract■ Verbal instructions are central to humans' capacity to learn new behaviors with minimal training, but the neurocognitive mechanisms involved in verbally instructed behaviors remain puzzling. Recent functional magnetic resonance imaging (fMRI) evidence suggests that the right middle frontal gyrus and dorsal premotor cortex (rMFG-dPMC) supports the translation of symbolic stimulus-response mappings into sensorimotor representations. Here, we set out to (1) replicate this finding, (2) investigate whether this region's involvement is specific to novel (vs. trained) instructions, and (3) study whether rMFG-dPMC also shows differences in its (voxel) pattern response indicative of general cognitive processes of instruction implementation. Participants were shown instructions, which they either had to perform later or merely memorize. Orthogonal to this manipulation, the instructions were either entirely novel or had been trained before the fMRI session. Results replicate higher rMFG-dPMC activation levels during instruction implementation versus memorization and show how this difference is restricted to novel, but not trained, instruction presentations. Pattern similarity analyses at the voxel level further reveal more consistent neural pattern responses in rMFG-dPMC during the implementation of novel versus trained instructions. In fact, this more consistent neural pattern response seemed to be specific to the first instruction presentation and disappeared after the instruction had been applied once. These results further support a role of rMFGdPMC in the implementation of novel task instructions and highlight potentially important differences in studying this region's gross activation levels versus (the consistency of ) its response patterns. ■

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Section: Introductionmentioning

confidence: 76%

Section: Regions Of Interestmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Encoding of Novel Verbal Instructions for Prospective Action in the Lateral Prefrontal Cortex: Evidence from Univariate and Multivariate Functional Magnetic Resonance Imaging Analysis

Bourguignon

Braem

Hartstra

et al. 2018

Journal of Cognitive Neuroscience

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Morphological patterns and spatial probability maps of the inferior frontal sulcus in the human brain

Nolan,

Loh,

Petrides

2024

Human Brain Mapping

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The inferior frontal sulcus (ifs) is a prominent sulcus on the lateral frontal cortex, separating the middle frontal gyrus from the inferior frontal gyrus. The morphology of the ifs can be difficult to distinguish from adjacent sulci, which are often misidentified as continuations of the ifs. The morphological variability of the ifs and its relationship to surrounding sulci were examined in 40 healthy human subjects (i.e., 80 hemispheres). The sulci were identified and labeled on the native cortical surface meshes of individual subjects, permitting proper intra‐sulcal assessment. Two main morphological patterns of the ifs were identified across hemispheres: in Type I, the ifs was a single continuous sulcus, and in Type II, the ifs was discontinuous and appeared in two segments. The morphology of the ifs could be further subdivided into nine subtypes based on the presence of anterior and posterior sulcal extensions. The ifs was often observed to connect, either superficially or completely, with surrounding sulci, and seldom appeared as an independent sulcus. The spatial variability of the ifs and its various morphological configurations were quantified in the form of surface spatial probability maps which are made publicly available in the standard fsaverage space. These maps demonstrated that the ifs generally occupied a consistent position across hemispheres and across individuals. The normalized mean sulcal depths associated with the main morphological types were also computed. The present study provides the first detailed description of the ifs as a sulcal complex composed of segments and extensions that can be clearly differentiated from adjacent sulci. These descriptions, together with the spatial probability maps, are critical for the accurate identification of the ifs in anatomical and functional neuroimaging studies investigating the structural characteristics and functional organization of this region in the human brain.

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On the efficiency of instruction-based rule encoding

et al. 2018

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There is more into ‘doing’ than ‘knowing’: The function of the right inferior frontal sulcus is specific for implementing versus memorising verbal instructions

Cited by 35 publications

References 39 publications

Encoding of Novel Verbal Instructions for Prospective Action in the Lateral Prefrontal Cortex: Evidence from Univariate and Multivariate Functional Magnetic Resonance Imaging Analysis

Encoding of Novel Verbal Instructions for Prospective Action in the Lateral Prefrontal Cortex: Evidence from Univariate and Multivariate Functional Magnetic Resonance Imaging Analysis

Morphological patterns and spatial probability maps of the inferior frontal sulcus in the human brain

On the efficiency of instruction-based rule encoding

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