There is No Association Between the Omega-3 Index and Depressive Symptoms in Patients With Heart Disease Who Are Low Fish Consumers

Cai, Shaoxin; Coates, Alison M.; Buckley, Jonathan D.; Berry, Narelle M.; Burres, Lisa; Beltrame, John F.; Howe, Peter R. C.; Schrader, G.

doi:10.1016/j.hlc.2016.07.003

Cited by 4 publications

(3 citation statements)

References 60 publications

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“…Heart diseases or systemic diseases significantly affect the target values of O3I. This value was 4.8% in patients with CHD who were reported to be low fish consumers [ 12 ]. A subset of patients participating in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Heart Failure (HF) study treated with omega-3 PUFAs (1 g/day) exhibited an increase in the O3I from 4.8 ± 1.7% to 6.7 ± 1.9% [ 13 ].…”

Section: Most Recent Data On the Omega-3 Index (O3i)mentioning

confidence: 99%

Omega-3 Index and Anti-Arrhythmic Potential of Omega-3 PUFAs

et al. 2017

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Omega-3 polyunsaturated fatty acids (PUFAs), namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are permanent subjects of interest in relation to the protection of cardiovascular health and the prevention of the incidence of both ventricular and atrial arrhythmias. The purpose of this updated review is to focus on the novel cellular and molecular effects of omega-3 PUFAs, in the context of the mechanisms and factors involved in the development of cardiac arrhythmias; to provide results of the most recent studies on the omega-3 PUFA anti-arrhythmic efficacy and to discuss the lack of the benefit in relation to omega-3 PUFA status. The evidence is in the favor of omega-3 PUFA acute and long-term treatment, perhaps with mitochondria-targeted antioxidants. However, for a more objective evaluation of the anti-arrhythmic potential of omega-3 PUFAs in clinical trials, it is necessary to monitor the basal pre-interventional omega-3 status of individuals, i.e., red blood cell content, omega-3 index and free plasma levels. In the view of evidence-based medicine, it seems to be crucial to aim to establish new approaches in the prevention of cardiac arrhythmias and associated morbidity and mortality that comes with these conditions.

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Section: Most Recent Data On the Omega-3 Index (O3i)mentioning

confidence: 99%

Omega-3 Index and Anti-Arrhythmic Potential of Omega-3 PUFAs

et al. 2017

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“…Similarly, Tu et al 22 reported that after feeding α-linolenic acid to weanling rats, the erythrocyte omega-3 index correlated positively with that of most other tissues, but not the brain. Some epidemiologic studies also showed no correlation between erythrocyte index and depression 39 or white matter hyperintensity 40 . Many experimental studies in animals, on the other hand, have reported a positive correlation between erythrocyte omega-3 index and that of the brain, but the range of brain DHA values achieved in these studies was narrow, since TAG-omega-3, which does not efficiently enrich brain omega-3, was used for feeding 19,22,41 .…”

Section: Discussionmentioning

confidence: 97%

Plasma BDNF is a more reliable biomarker than erythrocyte omega-3 index for the omega-3 fatty acid enrichment of brain

Sugasini

Rao

Subbaiah

2020

Sci Rep

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Enriching brain DHA is believed to be beneficial for the prevention and treatment of several neurological diseases, including Alzheimer's disease. An impediment in assessing the effectiveness of the treatments is the lack of a reliable biomarker for brain DHA. The commonly used erythrocyte omega-3 index is not suitable for brain because of the involvement of unique transporter at the blood brain barrier (BBB). We recently showed that dietary lysophosphatidylcholine (LPC)-DHA significantly increases brain DHA, which results in increase of brain BDNF. Since there is bidirectional transport of BDNF through the BBB, we tested the hypothesis that plasma BDNF may be used as biomarker for brain DHA enrichment. We altered the brain DHA in rats and mice over a wide range using different dietary carriers of DHA, and the correlations between the increase in brain omega-3 index with the increases in plasma BDNF and the erythrocyte index were determined. Whereas the increase in brain omega-3 index positively correlated with the increase in plasma BDNF, it negatively correlated with the erythrocyte index. These results show that the plasma BDNF is more reliable than the erythrocyte index as biomarker for assessing the effectiveness of omega-3 supplements in improving brain function.

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“… 52 Another study demonstrated that the omega-3 index was not associated with angina status measured by SAQ in patients with heart disease. 53 …”

Section: Discussionmentioning

confidence: 99%

Impact of Dietary Advanced Glycation End-Product Restriction on Insulin Resistance and Anthropometric Indices in Coronary Artery Patients Treated with Percutaneous Coronary Intervention: A Randomized Controlled Trial

Honarkar-Shafie¹,

Hosseinzadeh‐Attar²,

Taheri³

et al. 2023

JTHC

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Background: Insulin resistance (IR), even in its subclinical state, is a significant risk factor for the onset and progression of coronary artery disease (CAD). IR is a multifactorial condition, and dietary composition is a factor associated with its development. Elevated advanced glycation end products (AGEs) in the body, secondary to highly processed food consumption, can impair glucose metabolism. The present study investigated whether a restricted AGE diet could affect insulin sensitivity and anthropometric indices reflecting visceral adipose tissue in nondiabetic CAD patients. Methods: This trial randomly allocated 42 angioplasty-treated patients to follow either low-AGE or control diets based on the AHA/NCEP guidelines for 12 weeks. Serum levels of total AGEs, insulin, HbA1c, and fasting blood sugar, as well as anthropometric measurements, were evaluated before and after the intervention. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and anthropometric indices were calculated according to the proposed formula. The patients’ health status was assessed using the Seattle Angina Questionnaire (SAQ) at baseline and after the intervention. Results: Our study showed a significant reduction in anthropometric indices in the low-AGE group after 12 weeks. Insulin levels and IR decreased during the low-AGE diet. No significant changes were observed in the other serum biochemical markers. All SAQ domains significantly decreased in both groups, except for Treatment Satisfaction. Conclusion: A low-AGE diet for 12 weeks had beneficial effects on HOMA-IR and insulin levels in patients with CAD. Regarding the fundamental role of AGE in IR development and body fat distribution, AGE restriction may positively affect these patients.

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There is No Association Between the Omega-3 Index and Depressive Symptoms in Patients With Heart Disease Who Are Low Fish Consumers

Abstract: Background: Long chain omega-3 polyunsaturated fatty acids (LCn3PUFAs) may improve

Cited by 4 publications

References 60 publications

Omega-3 Index and Anti-Arrhythmic Potential of Omega-3 PUFAs

Omega-3 Index and Anti-Arrhythmic Potential of Omega-3 PUFAs

Plasma BDNF is a more reliable biomarker than erythrocyte omega-3 index for the omega-3 fatty acid enrichment of brain

Impact of Dietary Advanced Glycation End-Product Restriction on Insulin Resistance and Anthropometric Indices in Coronary Artery Patients Treated with Percutaneous Coronary Intervention: A Randomized Controlled Trial

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