There is no intraocular affection on a SARS-CoV-2 - Infected ocular surface

Lauermann, Peer; Storch, Marcus Werner; Weig, Michael; Tampe, Björn; Winkler, Martin Sebastian; Hoerauf, Hans; Feltgen, Nicolas; Hakroush, Samy

doi:10.1016/j.ajoc.2020.100884

Cited by 11 publications

(13 citation statements)

References 6 publications

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“…There is also evidence of SARS-CoV-2 RNA detection in the retinal biopsies of COVID-19 patients [19]. However, the results of a case report revealed no definitive SARS-CoV-2 RNA from the vitreous samples [20]. Besides the ACE receptor, CD147, a transmembrane glycoprotein, has been shown as another possible receptor for binding to the host cells [21].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Retinal Neurodegeneration and Choroidal Thickness in COVID-19 Patients Using Swept-Source OCT Technology

Çetinkaya

Kurt

Akpolat

2021

Klin Monbl Augenheilkd

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Purpose To analyze the central macular thickness (CMT), retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), and choroidal thickness (ChT) measurements in patients with coronavirus disease 2019 (COVID-19). Methods The study was conducted cross-sectionally 4 weeks after the completed treatment of COVID-19. The diagnosis of COVID-19 was based on the polymerase chain reaction test and/or clinical and radiological findings. The patients with treated COVID-19 were enrolled in the COVID-19 group; age- and sex-matched healthy participants served as the control group. All patients in the COVID-19 group were hospitalized and treated with favipiravir, moxifloxacin, and heparin without the requirement for intubation. The measurements of CMT, RNFLT (in four quadrants), GCLT (in six sectors of two different boundaries), and ChT (in five locations) were performed by swept-source optical coherence tomography (SS-OCT). Results Similar visual acuity (p = 0.582) and intraocular pressure (p = 0.766) values were observed between the COVID-19 and control groups. Regarding SS-OCT measurements, all mean CMT, RNFLT (in four quadrants), GCLT (in six sectors of two different boundaries), and ChT (in five locations) values were similar in the COVID-19 and control groups (p > 0.05 for all). In the COVID-19 group, a statistically significant negative correlation was noted between the mean ferritin level and temporal RNFLT (r = − 0.378, p = 0.014) and a positive correlation was observed between the mean ferritin level and nasal RNFLT (r = + 0.371, p = 0.016). Conclusion SS-OCT measurements showed no retinal neurodegenerative and choroidal thickness alterations in COVID-19 patients. Nonsignificant results might be due to the examination of the patients in the early period of the COVID-19 after the treatment. Therefore, late period OCT measurements should be reviewed with new studies in the future.

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Section: Discussionmentioning

confidence: 99%

Assessment of Retinal Neurodegeneration and Choroidal Thickness in COVID-19 Patients Using Swept-Source OCT Technology

Çetinkaya

Kurt

Akpolat

2021

Klin Monbl Augenheilkd

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“…None of the patient had any ocular manifestation in our study. SARS-CoV-2 wasn't detected in study done by List W et al [17] (16 cases), Lauermann P et al [18] (1 case) and Bayyoud T et al [19] (1 case). Recent studies have found SARS-CoV-2 in tear and conjuctival swabs in even in patients who hadn't any ocular manifestation.…”

Section: Resultsmentioning

confidence: 92%

“…Very few studies have focused on detection of SARS-CoV-2 in vitreous humor, CSF, pleural uid and pericardial uid. [17][18][19][20][21][22][23][24][25][26][27][28][29][30] Number of cases were also less in most such studies. In our study, we have collected postmortem samples of vitreous humor, CSF, pleural uid and pericardial uid in 24 cases and analyzed them to detect SARS-CoV-2 by RT-PCR.…”

Section: Introductionmentioning

confidence: 99%

Detection of SARS-CoV-2 in Different Body Fluids Using RT-PCR – An Autopsy Based Study

Kyada¹,

Trangadia²,

Vadgama³

et al. 2020

Preprint

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World is in mid of dreaded pandemic – Covid-19 caused by SARS-CoV-2. To curb it tremendous efforts has been put worldwide to enhance scientific knowledge related to SARS-CoV-2. In this study, we collected postmortem samples of tracheal swab, vitreous humor, pleural fluid, CSF and pericardial fluid by conducting complete autopsy on 24 patients with known SARS-CoV-2 infection at department of forensic medicine, P.D.U. Government College, Rajkot (India). RT-PCR was used to detect SARS-CoV-2 from these samples. SARS-CoV-2 was detected from tracheal swab in 54.55% cases and from pleural fluid in 13.34% cases. SARS-CoV-2 wasn’t detected from any sample of CSF, vitreous humor and pericardial fluid. Positive and negative cases for postmortem tracheal swabs were analyzed to find out of its relationship with duration of Covid-19 illness. No significant relationship was found between detectability of SARS-CoV-2 in postmortem samples of tracheal swab and duration of Covid-19 illness.

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Section: Covid-19 Pandemicmentioning

confidence: 99%

“…25 Recent evidence demonstrated the presence of SARS-CoV-2 in the vitreous and cornea, highlighting the criticality of donor screening guidelines and the plausibility of human eye tissue or eye fluids to be a source of infection. 24,26 The ocular manifestations of COVID-19 include mainly signs and symptoms compatible with follicular conjunctivitis. The incidence of conjunctivitis is estimated around 1% to 3% and is related in a meta-analysis to more severe forms of COVID-19.…”

Section: Sars-cov-2 and Eyementioning

confidence: 99%

A Year of Living Dangerously: Challenges and Recommendations for Safely Performing Ophthalmic Surgery During the COVID-19 Pandemic, from Start to Finish

Salica¹,

Potilinski²,

Querci³

et al. 2021

OPTH

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The COVID-19 pandemic has forced all nations to take an active role in infection control incorporating recommendations and measures to control viral dissemination. The epidemiological impact is very diverse and dynamic, even within the same region. Scientific knowledge regarding SARS-CoV-2 continues to improve every day with protocols needing to be updated and adjusted on a regular basis. Ophthalmology is a medical specialty identified to be at high risk for several reasons: it has very close doctor-patient contact, the virus has been detected in tears, and the ocular surface serves as a gateway to developing the infection. We have reviewed the current information on SARS-CoV-2 in the ophthalmologic field and provide up-to-date recommendations to help create protocols that can adapt to the dynamic situation of ophthalmologic institutions, patient cases, economic situations and access to diagnostic tests. This paper outlines the main recommendations regarding the initial consultation and outpatient clinics, measures to apply in the operating room (OR), and suggestions for post-surgical controls. Triage, according to the patient's conditions and eye pathology, reduction of the time the patient is at the institution, social distancing, correct use of personal protective equipment (PPE), barrier methods, hygiene, as well as other recommendations mentioned in this document, will allow physicians to take care of the visual health of the patients while reducing the impact of the COVID-19 pandemic.

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There is no intraocular affection on a SARS-CoV-2 - Infected ocular surface

Cited by 11 publications

References 6 publications

Assessment of Retinal Neurodegeneration and Choroidal Thickness in COVID-19 Patients Using Swept-Source OCT Technology

Assessment of Retinal Neurodegeneration and Choroidal Thickness in COVID-19 Patients Using Swept-Source OCT Technology

Detection of SARS-CoV-2 in Different Body Fluids Using RT-PCR – An Autopsy Based Study

A Year of Living Dangerously: Challenges and Recommendations for Safely Performing Ophthalmic Surgery During the COVID-19 Pandemic, from Start to Finish

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