Thermal analysis and calorimetric methods in the characterisation of polymorphs and solvates

Diversity in Single- and Multiple-Component Crystals. The Search for and Prevalence of Polymorphs and Cocrystals

“…Included are compendia of compounds that have been found to be polymorphic by research specific to that goal, such as the ones by Deffet, 63 Kuhnert-Brandstätter, 29 and Giron. 64 Bernstein wrote specifically about the occurrence of polymorphism in pharmaceuticals, noting that several compilations have appeared that contain references to several hundred compounds. 65 Attempts to estimate the frequency of polymorphism in organic compounds (what percentage display the property) have been sporadic.…”

A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism

“…Its application to characterise pharmaceutical products has been extensively reviewed in the literature [5][6][7][8][9]. One of the most widely used thermal analysis techniques for the investigation of polymorphism is differential scanning calorimetry (DSC).…”

Thermoanalytical study of purine derivatives compounds

“…Wendlandt and Collins [2] used DTA and TG as aids in the characterization and identification of commercial non-preescription analgesics. Other investigations of the use of thermoanalytical techniques for the study of drug substances and for applications in routine pharmaceutical analysis and in the pharmaceutical industry have also been described [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”