Thermal analysis and crystallization from melts

Canotilho, João; Castro, Ricardo A. E.; Rosado, Mário T. S.; Nunes, Sandra C.C.; Cruz, M. S. C.; Redinha, J.S.

doi:10.1007/s10973-009-0645-8

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Thermal methods are more and more used in pharmaceutical applications [29,30], both in drug development and in industrial processes. DSC and related techniques widely contribute to the study of, e.g., the stability of drugs [31][32][33], their polymorphism [34], and drug-excipient compatibility or chemical interactions [35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Phase diagram and dissolution studies of the fenofibrate–acetylsalicylic acid system

Gòrniak

Wojakowska

Karolewicz

et al. 2010

J Therm Anal Calorim

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Enhancement of the dissolution rate of poorly soluble compounds through the formation of drug-drug eutectics was investigated using fenofibrate and acetylsalicylic acid. Solid-liquid equilibria in the system under study were investigated by differential scanning calorimetry (DSC). The phase diagram for the whole range of compositions was constructed. In addition, existence of a metastable polymorph of fenofibrate has been confirmed. The investigation has revealed that acetylsalicylic acid and fenofibrate form a simple eutectic mixture containing 0.958 mol fraction of fenofibrate at the eutectic point. Dissolution rate improvement of fenofibrate correlated with the phase diagram. The amount of fenofibrate released from the solid dispersions that contained fenofibrate as the eutectic mixture with acetylsalicylic acid was at least threefold higher compared to untreated fenofibrate.

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Section: Introductionmentioning

confidence: 99%

Phase diagram and dissolution studies of the fenofibrate–acetylsalicylic acid system

Gòrniak

Wojakowska

Karolewicz

et al. 2010

J Therm Anal Calorim

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“…At storage temperatures near to and above glass transition, the rates of crystallization increased. On the other hand, the temperature dependence of molecular motions below the glass transition temperature is highly dependent upon conditions under which the glass was formed [27,[34][35][36][37][38]. Those molecular motions are consequences of relaxation of a sample.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and thermal study of new N-substituted 1H-pyrrolo[3,4-c]pyridine-1,3(2H)diones of Mannich base type

Krzyżak

Szczęśniak-Sięga

Szkatuła

et al. 2011

J Therm Anal Calorim

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The new derivatives of 3,4-pyridinedicarboximide were synthesised. Experimental measurements were carried out using 1 H NMR spectra, IR spectra, elemental analyses and differential scanning calorimetry. The purpose of this study was to study the thermal stability of these four new compounds and to establish a solid-state polymorphism. Measurements were carried out for samples obtained from ethanol and n-hexane and after a long-time storage.

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Investigation on the thermal behavior of β-blockers antihypertensives atenolol and nadolol using TG/DTG, DTA, DSC, and TG–FTIR

Amorim

Ferreira

Machado

et al. 2015

J Therm Anal Calorim

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Thermal analysis and crystallization from melts

Cited by 5 publications

References 25 publications

Phase diagram and dissolution studies of the fenofibrate–acetylsalicylic acid system

Phase diagram and dissolution studies of the fenofibrate–acetylsalicylic acid system

Synthesis and thermal study of new N-substituted 1H-pyrrolo[3,4-c]pyridine-1,3(2H)diones of Mannich base type

Investigation on the thermal behavior of β-blockers antihypertensives atenolol and nadolol using TG/DTG, DTA, DSC, and TG–FTIR

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