Thermal Analysis in the Rat Glioma Model During Directly Multipoint Injection Hyperthermia Incorporating Magnetic Nanoparticles

Abstract

Hyperthermia incorporating magnetic nanoparticles (MNPs) is a hopeful therapy to cancers and steps into clinical tests at present. However, the clinical plan of MNPs deposition in tumors, especially applied for directly multipoint injection hyperthermia (DMIH), and the information of temperature rise in tumors by DMIH is lack of studied. In this paper, we mainly discussed thermal distributions induced by MNPs in the rat brain tumors during DMIH. Due to limited experimental measurement for detecting thermal dose of tumors, and in order to acquire optimized results of temperature distributions clinically needed, we designed the thermal model in which three types of MNPs injection for hyperthermia treatments were simulated. The simulated results showed that MNPs injection plan played an important role in determining thermal distribution, as well as the overall dose of MNPs injected. We found that as injected points enhanced, the difference of temperature in the whole tumor volume decreased. Moreover, from temperature detecting data by Fiber Optic Temperature Sensors (FOTSs) in glioma bearing rats during MNPs hyperthermia, we found the temperature errors by FOTSs reduced as the number of points injected enhanced. Finally, the results showed that the simulations are preferable and the optimized plans of the numbers and spatial positions of MNPs points injected are essential during direct injection hyperthermia.

Establishment of C6 brain glioma models through stereotactic technique for laser interstitial thermotherapy research

“…The C6 glioma models produced by inoculation of standard quantitative C6 brain cells into the rat brain with stereotactic technique were the earliest as well as most widely and commonly applied models. [ 2 11 19 ] With continuously improving inoculation technology, to explore inoculation repeatability, Morreale[ 12 ] had inserted stainless steel tubes into rat caudate nucleus. Although inoculation channel could be realized through these methods, they posed several disadvantages.…”

“…The fastest tumor growing period was between 2 and 3 weeks, and then the speed of growth slowed down dramatically. According to the tumor growth characteristics of the model, it is generally believed that the advisable time of experiment treatment were between 5 and 10 days,[ 6 11 16 19 ] during which the interstitial thermotherapy, chemotherapy, drug intervention, or immunotherapy could be completed. In the present experiment, we confirmed that capillary hyperplasia and the blood–brain barrier structure was present in rat glioma models, which presented high similarity with human glioma in terms of histopathological characteristics.…”

“…Except LITT, nanoshell-mediated laser photothermal therapy represents a promising novel treatment strategy for malignant glioma. Thermal analysis assisted with MR temperature mapping in the rat glioma model during hyperthermia that incorporated magnetic nanoparticles (MNPs) was real-time and noninvasive, but required nonmagnetic therapeutic environment,[ 9 11 ] which makes it impractical in LITT.…”

Bionanotechnology and the Future of Glioma

“…[ 153 154 ] A wide range of preclinical studies in animals have demonstrated significant survival benefit in glioma when using superparamagnetic iron oxide NPs followed by magnetic hyperthermia. [ 78 104 186 ] This success prompted human clinical trials based in Germany using an aminosilane-coated iron oxide NP, with magnetic thermotherapy added to conventional treatment. The first results were published in 2007,[ 77 111 ] and the most recent were published in 2011.…”

Spectral-optical Properties of Nutrient Coated Optical Fibers for Glioma Cells Growth Orientation

“…Laser therapy and hyperthermia for glioblastoma multiforme are considered to be the part of a growing armamentarium for malignant glioma treatment [7][8]. The development of user-friendly fiber-optic toolkit, which allows obtaining spectral information during surgery and relapse observation, is very urgent [9]. To control tumor cells spreading and enhance the likelihood of their proliferation along the neuro-scaffold to the external surface, it is suggested to coat optical fibers with nutrient compound layer [10] (Figure 1).…”