Thermal analysis used to guide the production of thymol and Lippia origanoides essential oil inclusion complexes with cyclodextrin

Pires, Felipe Q.; Pinho, Ludmila A.G.; Freire, Daniel; Silva, Izabel C. R.; Barreto, Lívia Cristina Lira de Sá; Cardozo‐Filho, Lúcio; Gratieri, Taís; Gelfuso, Guilherme M.; Cunha-Filho, Marcílio

doi:10.1007/s10973-018-7956-6

Cited by 36 publications

(22 citation statements)

References 25 publications

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“…The diffractograms of the RV products showed no drug’s crystal signals, demonstrating the amorphous state of products probably due to their protection of PX in the cavity of CDs cyclodextrins. The results obtained in the current study are in agreement with previous studies reporting on the complexation of Hp-β-CD [14], Me-β-CD, and β-CD with PX [24].…”

Section: Resultssupporting

confidence: 93%

“…Physical mixtures shows the presence of both components (PX and CD). The FI-IR spectra of native Hp-β-CD, Me-β-CD, and β-CD are in broad agreement with previous reported data [14,24], whereas characteristic peaks attributed to the presence of PXM are clearly visible in the dominant physical mixtures. In the case of the inclusion complexes, broadened peaks are the dominating features in the spectra in accordance with previous studies [14,24].…”

Section: Resultssupporting

confidence: 91%

“…Thermograms of HP-β-CD showed the same thermal profile of dehydratation (60–100 °C) seen in the previous system and the disappearance of the melting peak of the pure drug in RV products. Furthermore, these findings for RV products could show an in situ inclusion complex formation, according to other studies involving drugs inclusion complexes with CDs [24,25].…”

Section: Resultssupporting

confidence: 76%

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In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

et al. 2019

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In the current study, the development of mucoadhesive tablets for buccal delivery of a non-steroidal anti-inflammatory drug was investigated. Binary complexes with piroxicam and cyclodextrins (β-cyclodextrin (β-CD), methylated-β-cyclodextrin (Me-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD)) were prepared by the co-evaporation method. All formulations were characterized by means of differential scanning calorimetry, infrared spectroscopy and powder X-ray diffractometry. Mucoadhesive tablets of binary systems were formulated by direct compression using chitosan as mucoadhesive polymer. The in vitro release profiles of tablets were conducted in simulated saliva and, the drug permeation studies, across porcine buccal mucosa. The results suggest that the rank order effect of cyclodextrins for the drug release was Me-β-CD > HP-β-CD > β-CD, whereas the ex vivo studies showed that the tablets containing chitosan significantly increased the transport of the drug compared to their free complexes. Finally, histological assessment revealed loss of the superficial cell layers, which might be attributed to the presence of cyclodextrins.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 76%

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In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

et al. 2019

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“…The spectra were recorded between 4000 and 600 cm −1 at an optical resolution of 4 cm −1 using an attenuated total reflection device. The correlation coefficient between fresh and aged samples [28] was calculated using the FTIR Essential software (Operant LLC, Madison, WIS, USA).…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

“…Moreover, the drug content of all formulations fulfills the pharmacopoeial range of 90-110% [40]. Moreover, a high correlation index was observed among the spectra of the fresh and aged samples for all extrudates (r > 0.9, Table 2), providing evidence that the chemical integrity of these systems would also be maintained during the shelf period [28]. Regarding the morphological aspects, the extrudate granules showed a regular size and a rounded shape (Figure 2).…”

Section: Extrusion Conditions and Sample Agingmentioning

confidence: 99%

Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products

et al. 2020

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Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 °C to preserve the stability of the effervescent salts. Formulations showed vigorous and rapid effervescent disintegration (<3 min), adequate flow characteristics, and complete solubilization of paracetamol instantly after the effervescent reaction. Formulations containing PVPVA in the concentration range of 15–20% m/m were demonstrated to be sensitive to accelerated aging conditions, undergoing marked microstructural changes, since the capture of water led to the agglomeration and loss of their functional characteristics. HPMC matrices, in contrast, proved to be resistant to storage conditions in high relative humidity, showing superior performance to controls, including the commercial product. Moreover, the combined mixture design allowed us to identify significant interactions between the polymeric materials and the disintegrating agents, showing the formulation regions in which the responses are kept within the required levels. In conclusion, this study demonstrates that HME can bring important benefits to the elaboration of effervescent drug products, simplifying the production process and obtaining formulations with improved characteristics, such as faster disintegration, higher drug solubilization, and better stability.

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Polymeric composites of 1,2,4-thiadiazole: solubility, dissolution and permeability assay

Volkova

Domanina

Chislov

et al. 2019

J Therm Anal Calorim

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Thermal analysis used to guide the production of thymol and Lippia origanoides essential oil inclusion complexes with cyclodextrin

Cited by 36 publications

References 25 publications

In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products

Polymeric composites of 1,2,4-thiadiazole: solubility, dissolution and permeability assay

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