Thermal dose as a universal tool to evaluate nanoparticle-induced photothermal therapy

Happonen, Emilia; Tamarov, Konstantin; Martikainen, Maria-Viola; Ketola, Kirsi; Roponen, Marjut; Lehto, Vesa‐Pekka; Xu, Wujun

doi:10.1016/j.ijpharm.2020.119657

Cited by 15 publications

(7 citation statements)

References 35 publications

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“…[187] Heating up to 50°C with continuous laser irradiation and NPs in suspension-triggered cellular apoptosis; the time for switching between apoptotic and secondary necrotic states decreased when the temperature increased. [188] Apoptosis is a highly regulated process and a so-called "safe" way to induce cell death, as it is determined by a stringently controlled process of cell degradation with the subse-quent clearance of the dead cell by the phagocytic system. On the other hand, necrosis is an unregulated process characterized by the rupture of the cellular membrane and the release of cell compartments.…”

Section: Thermal Dosementioning

confidence: 99%

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Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

Wen

Tamarov

Happonen

et al. 2020

Advanced Therapeutics

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Inorganic photothermal agents (PTAs) have attracted considerable attention in cancer theranostics due to their unique features such as high photothermal conversion efficacy, excellent photothermal stability, and straightforward functionalization. The first part of this Review summarizes progress in methods for synthesizing PTAs, then considers in vitro photothermal evaluations, as well as in vivo photothermal-based applications that attempt to overcome different barriers in cancer theranostics. Next, a clinical trial with an inorganic PTA is described. The final part of the Review examines the challenges and possibilities for successful transfer of inorganic PTAs from the laboratory to the clinic.

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Section: Thermal Dosementioning

confidence: 99%

“…Recently, we applied a simpler concept of a thermal isoeffect dose (TID) model to compare the results of cell viability assays and flow cytometry in vitro. [188] The TID model is based on the Arrhenius analysis of cell death rate [190] and can be expressed as cumulative equivalent minutes (CEM) at 43°C.…”

Section: Thermal Dosementioning

confidence: 99%

Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

Wen

Tamarov

Happonen

et al. 2020

Advanced Therapeutics

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“…In addition, the recently developed black PSi (BPSi) has superior photothermal conversion performance, as compared to the widely used nanomaterials such as carbon nanotubes [ 14 ]. Thus, the BPSi NPs have been successfully used for photothermal therapy and photoacoustic tomography [ 14 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental Evaluation of Radiation Response and Thermal Properties of NPs-Loaded Tissues-Mimicking Phantoms

Asadi

Korganbayev

et al. 2022

Nanomaterials

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Many efforts have recently concentrated on constructing and developing nanoparticles (NPs) as promising thermal agent for optical hyperthermia and photothermal therapy. However, thermal energy transfer in biological tissue is a complex process involving different mechanisms such as conduction, convection, radiation. Therefore, having information about thermal properties of tissue especially when NPs are embedded in is a necessity for predicting the heat transfer during hyperthermia. In this work, the thermal properties of solid phantom based on agar in the presence of three different nanoparticles (BPSi, tNAs, GNRs) and alone were measured and reported as a function of temperature (ranging from 22 to 62 °C). The thermal response of these NPs to an 808 nm laser beam with three different powers were studied in the water comparatively. Agar and tNAs have almost constant thermal properties in the considered range. Among the three NPs, gold has the highest conductivity and diffusivity. At 62 °C BPSi NPs have the similar amount of increase for the diffusivity. The thermal parameters reported in this paper can be useful for the mathematical modeling. Irradiation of the NPs-loaded water phantom displayed the highest radiosensitivity of gold among the three mentioned NPs. However, for the higher power of irradiation, BPSi and tNAs NPs showed the increased absorption of heat during shorter time and the increased temperature gradient slope for the initial 15 s after the irradiation started. The three NPs showed different thermal and irradiation response behavior; however, this comparison study notes the worth of having information about thermal parameters of NPs-loaded tissue for pre-clinical planning.

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“…Besides inhibiting tumor growth by necrosis and apoptosis 10,11 , multiple cancer-related studies have reported the application of feverrange HT as an immunotherapeutic agent 12 . HT was reported to stimulate the activation of antigen presenting cells (APCs) by releasing the heat shock protein (Hsp) from the dying heat-stressed cancer cells 13 .…”

Section: Introductionmentioning

confidence: 99%

Hyperthermia by Near Infrared Radiation Induced Immune Cells Activation and Infiltration in Breast Tumor

Zawawi

Hibma

Salim

et al. 2021

Preprint

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Breast cancer is the most common cancer that causes death in women. Conventional therapies, including surgery and chemotherapy, have different therapeutic effects and are commonly associated with risks and side effects. Near infrared radiation is a technique with few side effects that is used for local hyperthermia, typically as an adjuvant to other cancer therapies. The understanding of the use of near NIR as a monotherapy, and its effects on the anti-tumour immune response, is limited. In this study we investigate the effects of HT treatment using NIR on tumor regression and on the anti-tumor immune response in breast tumors. Results demonstrated that local HT by NIR at 43oC reduced tumor progression and prolonged the survival of tumor-bearing mice. Immunohistochemical analysis revealed a significant reduction in proliferation in treated tumor, which was accompanied by an abundance of heat shock protein 70 (Hsp70). Increased numbers of activated dendritic cells were observed in the draining lymph nodes of the mice, along with infiltration of T cells, NK cells and B cells into the tumor. In contrast, tumor-infiltrated regulatory T cells were largely diminished from the tumor. In addition, higher IFN-γ and lower IL-10 secretion was observed in blood of treated mice. Overall, this present study extends the understanding of using local HT by NIR to stimulate a favourable anti-tumor immune response against breast cancer.

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Thermal dose as a universal tool to evaluate nanoparticle-induced photothermal therapy

Cited by 15 publications

References 35 publications

Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

Experimental Evaluation of Radiation Response and Thermal Properties of NPs-Loaded Tissues-Mimicking Phantoms

Hyperthermia by Near Infrared Radiation Induced Immune Cells Activation and Infiltration in Breast Tumor

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