Thermal male contraception: A study of users’ motivation, experience, and satisfaction

Joubert, Samuel; Tcherdukian, Jessica; Mieusset, R.

doi:10.1111/andr.13264

Cited by 4 publications

(2 citation statements)

References 47 publications

(92 reference statements)

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“…Table 2). For the purposes of this review, only male contraceptives with a demonstrated pharmacological mechanism are discussed in detail, although thermal and vas-occlusive methods of reversible male contraception are in development and rely on thermal dysregulation of spermatogenesis, and obstructive, dissolvable, or degradable implants, respectively ( Lohiya et al, 2001 ; Soufir, 2017 ; Khourdaji et al, 2018 ; Long et al, 2021 ; Joubert et al, 2022 ).…”

Section: Novel Methods Currently In Developmentmentioning

confidence: 99%

Nonhormonal Male Contraceptive Development—Strategies for Progress

Nickels,

Yan

2023

Pharmacol Rev

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Despite the widely demonstrated public health benefits of contraception, limited contraceptive options are available for men, placing both the contraceptive burden and opportunity solely on women. This review outlines the need for an increased focus on male contraceptive development and highlights several related topics, including the perspectives of women and men on male contraceptives, historical challenges, and reasons behind the persistent delays in male contraceptive development. It also discusses the importance of serendipitous observations in drug discovery and the limitations of depleting sperm or spermatogenic cells as a contraceptive approach. It further provides an overview of ongoing research and development on novel methods, with a goal to offer insights into the multifaceted aspects of nonhormonal male contraceptive development, addressing its implications for the health of men and women. Significance Statement Despite well over half a century of effort in developing male contraceptives, there are no approved male contraceptive drugs on the market. This review aims to present strategies for progress in nonhormonal male contraception based on lessons learned from history, with the hope of expediting development and bringing a male contraceptive drug closer to reality.

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Section: Novel Methods Currently In Developmentmentioning

confidence: 99%

Nonhormonal Male Contraceptive Development—Strategies for Progress

Nickels,

Yan

2023

Pharmacol Rev

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“…66,67 Importantly, thermal male contraception appears to be reasonably well tolerated, with most men who use this method reporting that they would recommend it to others. 68 However, this method has not been approved for widespread use and has not been adopted by large numbers of men.…”

Section: Thermal Male Contraceptionmentioning

confidence: 99%

Male Contraception

Amory

2023

Semin Reprod Med

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Approximately 40 to 50% of pregnancies are unintended. Contraceptive use significantly reduces the risk of unintended pregnancy. Approximately 70% of couples' contraceptive use is female and 30% is male, attributable to the reliance on condoms and vasectomies. Unfortunately, many women cannot use currently available contraceptives due to medical contraindications or side effects. At the same time, men want additional safe and effective contraceptive methods. Because of this, work to develop novel, safe, and effective male contraceptives is underway. This review will briefly discuss the pros and cons of condoms and vasectomies, and then describe research into the development of novel methods of male contraception, by the mechanism of action of the contraceptive. First, we will discuss male contraceptives that block sperm transmission. Next, we will discuss male contraceptives that impair sperm production. Lastly, we will discuss male contraceptives that impair sperm function.

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Real‐life users of hormonal or thermal male contraception: An analysis of female partners’ motivation, experience, and satisfaction

Laurent,

Mieusset,

Soufir

et al. 2024

Andrology

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BackgroundTwo male contraceptive methods that inhibit spermatogenesis currently exist: thermal male contraception and hormonal male contraception. Only five studies have been conducted on the acceptability of these methods among men; among women, only the hypothetical acceptability of such a male contraceptive approach as the sole contraception method used by a couple has been evaluated.ObjectivesTo evaluate the motivation, experience, and satisfaction of female partners in couples using hormonal male contraception or thermal male contraception as the sole contraception.Materials and methodsIn this cross‐sectional study, 123 male users of hormonal male contraception or thermal male contraception as the couple's sole contraception method were asked to invite their female partner to participate in an anonymous online survey. The questionnaire included 95 questions exploring population characteristics, contraceptive and pregnancy history, motivations for choosing hormonal male contraception or thermal male contraception, the experience of the women in the successive phase of use, relationships with their partner, and satisfaction with the contraception method.ResultsThe response rate among participating women was 69% (59/86). The two main reasons for choosing male contraceptive were the desire to share the contraception role in the couple (65%) and the desire of the man to take charge of the contraception (61%). The sexual satisfaction score increased significantly between the contraceptive methods used before hormonal male contraception or thermal male contraception and the phase of contraceptive use (p < 0.01). The overall satisfaction level with thermal male contraception or hormonal male contraception was rated at 3.7 ± 0.6 out of 4. Women mostly recommended hormonal male contraception or thermal male contraception because of the share of contraceptive responsibility and mental load (n = 23/54, 43%).DiscussionThis population of women seemed to have struggled to find a contraceptive method that suited them, but most took advantage of thermal male contraception or hormonal male contraception and trusted their male partner to take charge of contraception use.ConclusionThe positive evaluation from women in partnerships using thermal male contraception and hormonal male contraception should encourage the development of these methods.

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Thermal male contraception: A study of users’ motivation, experience, and satisfaction

Cited by 4 publications

References 47 publications

Nonhormonal Male Contraceptive Development—Strategies for Progress

Nonhormonal Male Contraceptive Development—Strategies for Progress

Male Contraception

Real‐life users of hormonal or thermal male contraception: An analysis of female partners’ motivation, experience, and satisfaction

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