This research evaluates the operational heating and cooling energy consumption of cross-laminated timber (CLT) office buildings in China. The evaluations involve a comparison of the energy consumption of a reference RC structure and CLT system office buildings. Computational simulation results are based on IES-VE 2019 and show that the estimated heating energy saving ratio of CLT buildings in Harbin, Beijing, Shanghai, and Kunming to the reference structure are 11.97%, 22.11%, 30.94%, and 23.30% respectively. However, the CLT buildings consume more energy for cooling in the summer. The results of the research show significantly higher heating energy reductions for CLT buildings in the Cold Region and Severe Cold Regions of China. Thus, the application of the CLT system is better suited to northern China than southern China. The results of the research can be used in further assessment of the use of CLT systems in different climatic regions in China.