Thermal, spectral, magnetic and biologic characterization of new Ni(II), Cu(II) and Zn(II) complexes with a hexaazamacrocyclic ligand bearing ketopyridine moieties

Badea, Mihaela; Pătraşcu, Florentina; Korošec, Romana Cerc; Bukovec, Peter; Raita, Monica; Chifiriuc, Mariana Carmen; Măruţescu, Luminiţa; Bleoţu, Coralia; Velescu, Bruno Ştefan; Marinescu, Dana; Uivaroşi, Valentina; Olar, Rodica

doi:10.1007/s10973-014-3857-5

Cited by 11 publications

(8 citation statements)

References 46 publications

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“…Inflammation was evaluated in two acute inflammation experimental models by plethysmometry as reported [38]. The anti-inflammatory effect was compared with a control group (untreated rats), a reference substance (diclofenac) and a group treated with the ligand.…”

Section: Anti-inflammatory Assaysmentioning

confidence: 99%

Thermal behaviour of some biologically active species based on complexes with a triazolopyrimidine pharmacophore

Olar

Calu

Badea

et al. 2016

J Therm Anal Calorim

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A series of complexes of type M(pmtp)(CH 3 COO) 2 ÁnH 2 O ((1) M: Co, n = 4.5; (2) M: Ni, n = 3.5; (3) M: Cu, n = 0.5; (4) M: Zn, n = 0; pmtp: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesised by one-pot condensation. The complexes were characterized by elemental analysis, ESI-MS, IR, UV-Vis-NIR, EPR spectra, magnetic susceptibility at room temperature as well as thermogravimetric analysis. The modifications in the IR spectra of complexes are in accordance with the condensation process and indicate the triazolopyrimidine coordination as unidentate. The electronic and EPR spectra together with magnetic moments indicate an octahedral stereochemistry for paramagnetic ions, except for Cu(II) with a square pyramidal geometry. Processes such as water elimination, acetate into carbonate transformation, as well as oxidative degradation of the triazolopyrimidine derivative were evidenced during thermal decomposition. The complexes exhibited an improved antimicrobial activity in comparison with the ligand, on both planktonic and biofilm-embedded microbial cells. The best antimicrobial activity in both susceptible and resistant strains was obtained for complex (3) followed by complex (1), which can be related to both oxidation state and stereochemical versatility. At high concentrations, the Cu(II) complex exhibits both cytotoxicity on HT 29 tumour cell line and anti-inflammatory activity.

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Section: Anti-inflammatory Assaysmentioning

confidence: 99%

Thermal behaviour of some biologically active species based on complexes with a triazolopyrimidine pharmacophore

Olar

Calu

Badea

et al. 2016

J Therm Anal Calorim

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“…Temperature was kept between 20 and 22 °C, while the relative humidity was maintained at 35-45%. Inflammation was evaluated in two inflammation experimental models by plethysmometry (Ugo Basile 7140 Plethysmometer), as previously reported [ 38 ].…”

Section: Methodsmentioning

confidence: 99%

Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills

Fierăscu

Ungureanu

Avramescu

et al. 2018

BMC Complement Altern Med

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BackgroundJuniperus communis L. represents a multi-purpose crop used in the pharmaceutical, food, and cosmetic industry. Several studies present the possible medicinal properties of different Juniperus taxa native to specific geographical area. The present study aims to evaluate the genoprotective, antioxidant, antifungal and anti-inflammatory potential of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills.MethodsThe prepared hydroethanolic extract of Juniperus communis L. was characterized by GC-MS, HPLC, UV-Vis spectrometry and phytochemical assays. The antioxidant potential was evaluated using the DPPH assay, the antifungal effect was studied on Aspergillus niger ATCC 15475 and Penicillium hirsutum ATCC 52323, while the genoprotective effect was evaluated using the Allium cepa assay. The anti-inflammatory effect was evaluated in two inflammation experimental models (dextran and kaolin) by plethysmometry. Male Wistar rats were treated by gavage with distilled water (negative control), the microemulsion (positive control), diclofenac sodium aqueous solution (reference) and microemulsions containing juniper extract (experimental group). The initial paw volume and the paw volumes at 1, 2, 3, 4, 5 and 24 h were measured.ResultsTotal terpenoids, phenolics and flavonoids were estimated to be 13.44 ± 0.14 mg linalool equivalent, 19.23 ± 1.32 mg gallic acid equivalent, and 5109.6 ± 21.47 mg rutin equivalent per 100 g of extract, respectively. GC-MS characterization of the juniper extract identified 57 volatile compounds in the sample, while the HPLC analysis revealed the presence of the selected compounds (α-pinene, chlorogenic acid, rutin, apigenin, quercitin). The antioxidant potential of the crude extract was found to be 81.63 ± 0.38% (measured by the DPPH method). The results of the antifungal activity assay (for Aspergillus niger and Penicillium hirsutum) were 21.6 mm, respectively 17.2 mm as inhibition zone. Test results demonstrated the genoprotective potential of J. communis undiluted extract, inhibiting the mitodepressive effect of ethanol. The anti-inflammatory action of the juniper extract, administered as microemulsion in acute-dextran model was increased when compared to kaolin subacute inflammation induced model.ConclusionThe hydroalcoholic extract obtained from wild-growing Juniperus communis native to Romanian southern sub-Carpathian hills has genoprotective, antioxidant, antifungal and anti-inflammatory properties.

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“…e softness index was on the contrary to global stiffness. e suggested structures were supported by these parameters, and the mentioned quantum chemical parameters were studied through the recommended equations [39][40][41].…”

Section: Structural Interpretationmentioning

confidence: 99%

Synthesis, Spectroscopic Characterization, Molecular Docking, and Evaluation of Antibacterial Potential of Transition Metal Complexes Obtained Using Triazole Chelating Ligand

Al‐Radadi

Zayed

Salam

2020

Journal of Chemistry

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Mononuclear chelates of Ni(II), Co(II), Fe(III), Cd(II), and Cu(II) derived from triazole novel tridentate ligands were prepared and characterized by different spectroscopic methods. The metal to ligand ratio was 1 : 2, which was revealed by elemental analysis. All the complexes were electrolytic in nature as suggested by the conductivity measurements. IR pointed out that the coordination of the triazole ligand toward the metal ions was carried out through N amino and S thiophenolic atoms. The complexes were found to have octahedral geometry, and their thermal stability was also studied. The XRD spectrum of Co(II) and Fe(III) complexes concluded their crystalline structure. The parent ligand and its chelates were investigated for antimicrobial potential. Bioassay of all triazole complexes showed increased activity as compared to that of the ligand. The complexes having Ni(II), Co(II), and Cu(II) ions as metal center exhibited superior antibacterial activity in opposition to Gram-positive (B. subtilis and S. pyogenes) and Gram-negative (E. coli and P. vulgaris) bacterium as compared to standard.

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Thermal, spectral, magnetic and biologic characterization of new Ni(II), Cu(II) and Zn(II) complexes with a hexaazamacrocyclic ligand bearing ketopyridine moieties

Cited by 11 publications

References 46 publications

Thermal behaviour of some biologically active species based on complexes with a triazolopyrimidine pharmacophore

Thermal behaviour of some biologically active species based on complexes with a triazolopyrimidine pharmacophore

Genoprotective, antioxidant, antifungal and anti-inflammatory evaluation of hydroalcoholic extract of wild-growing Juniperus communis L. (Cupressaceae) native to Romanian southern sub-Carpathian hills

Synthesis, Spectroscopic Characterization, Molecular Docking, and Evaluation of Antibacterial Potential of Transition Metal Complexes Obtained Using Triazole Chelating Ligand

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