Thermal spray processes influencing surface chemistry and in-vitro hemocompatibility of hydroxyapatite-based orthopedic implants

Shankar, Deep; Jayaganesh, K.; Gowda, Niranjan; Lakshmi, K.S.; Jayanthi, K.J.; Jambagi, Sudhakar C.

doi:10.1016/j.bioadv.2024.213791

Biomaterials Advances

2024

DOI: 10.1016/j.bioadv.2024.213791

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Thermal spray processes influencing surface chemistry and in-vitro hemocompatibility of hydroxyapatite-based orthopedic implants

Deep Shankar,

K. Jayaganesh,

Niranjan Gowda

et al.

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2024

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Cited by 7 publications

References 92 publications

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Enhancement of the Mechanical Properties and Biological Performance of Hydroxyapatite Coating by Selenium and Fluorine Ion Codoping

Zhang,

Bai,

et al. 2024

Adv Eng Mater

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Ion doping is a feasible method to improve the mechanical and biological properties of hydroxyapatite (HA) as an implant coating material. F and Se codoped HA (SeF‐HA) powder is synthesized with the method of chemical codeposition and directly used for coating preparation via suspension plasma spray technology. Various characterizations indicate that F and Se ions have been codoped into the HA structure by substituting OH− and PO43− groups, respectively. The SeF‐HA coatings exhibit excellent adhesion strength with the substrate, fully meeting the ISO requirement of 15 MPa. The dissolution behavior is investigated by immersing the coatings in simulated body fluid for different durations. The results show that the dissolution rate of the SeF‐HA coatings is lower than that of the single Se‐doped HA coating, suggesting an improvement in the stability of the SeF‐HA coating. The in vitro studies show that the SeF‐HA coating can promote the osteogenic activity of osteoblasts and has an antiproliferative effect on osteosarcoma cells. Based on these results, it can be concluded that the combined effects of Se and F can make suspension plasma sprayed HA coating a potential coating material for dental implants or for bone tissue repair in osteosarcoma patients.

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Enhancement of the Mechanical Properties and Biological Performance of Hydroxyapatite Coating by Selenium and Fluorine Ion Codoping

Zhang,

Bai,

et al. 2024

Adv Eng Mater

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Yuan,

Zhu,

Yang

et al. 2024

Advanced Materials

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The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, and congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these severe bone defects, without incurring prevalent complications associated with conventional autologous or allogeneic bone grafts. 3D printing technology enables control over architectural structures at multiple length scales and has been extensively employed to process biomimetic scaffolds for BTE. In contrast to inert and functional bone grafts, next‐generation smart scaffolds possess a remarkable ability to mimic the dynamic nature of native extracellular matrix (ECM), thereby facilitating bone repair and regeneration. Additionally, they can generate tailored and controllable therapeutic effects, such as antibacterial or antitumor properties, in response to exogenous and/or endogenous stimuli. This review provides a comprehensive assessment of the progress of 3D‐printed smart scaffolds for BTE applications. It begins with an introduction to bone physiology, followed by an overview of 3D printing technologies utilized for smart scaffolds. Notable advances in various stimuli‐responsive strategies, therapeutic efficacy, and applications of 3D‐printed smart scaffolds are discussed. Finally, the review highlights the existing challenges in the development and clinical implementation of smart scaffolds, as well as emerging technologies in this field.

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Electrochemical Corrosion Analysis of HA-Based Coating Deposited Using LVOF Technique on Austenitic Stainless Steel Surgical Grade

Bafila,

Vasudev

2024

J. Inst. Eng. India Ser. D

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Thermal spray processes influencing surface chemistry and in-vitro hemocompatibility of hydroxyapatite-based orthopedic implants

Cited by 7 publications

References 92 publications

Enhancement of the Mechanical Properties and Biological Performance of Hydroxyapatite Coating by Selenium and Fluorine Ion Codoping

Enhancement of the Mechanical Properties and Biological Performance of Hydroxyapatite Coating by Selenium and Fluorine Ion Codoping

Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Electrochemical Corrosion Analysis of HA-Based Coating Deposited Using LVOF Technique on Austenitic Stainless Steel Surgical Grade

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