Thermal stability and thermal decomposition of the antihypertensive drug amlodipine besylate

Silva, A. C. M.; Gálico, Diogo A.; Guerra, Renan Barrach; Perpétuo, Glauco Lini; Legendre, Alexandre; Rinaldo, Daniel; Bannach, Gilbert

doi:10.1007/s10973-014-3992-z

Cited by 26 publications

(12 citation statements)

References 23 publications

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“…TG-FTIR is widely used to analyze the gaseous products during the thermal decomposition [12,23,24]. The three-dimensional diagrams of infrared absorption of evolved gas products versus time and wavenumber during the thermal decomposition processes are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Thermoanalytical techniques have been widely applied in the pharmaceutical field for several purposes including purity determination for drugs, composition analysis of drugs and raw materials, melting point testing, crystal formation and change tests, thermal stability of medicines, evaluation of the validity, thermal decomposition kinetics, identification of natural drugs, and optimization for production of drugs [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Study on the thermal decomposition of capecitabine

Wang

You

2015

J Therm Anal Calorim

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The thermal decomposition of capecitabine (CAP) was measured with thermogravimetry, differential scanning calorimetry, and thermogravimetric analysis coupled with Fourier transform infrared spectroscopy. The IR spectra, high-performance liquid chromatography, and liquid chromatography-mass spectrometry of CAP and the residue of its thermal decomposition at various temperatures were determined. The molecular bond orders were calculated using an ab initio method from the GAMESS program of quantum chemistry. The mode of thermal decomposition for CAP was discussed. The kinetic parameters for thermal decomposition such as activation energy E a and the pre-exponential factor A were obtained using the Ozawa method. The prospective lifetime of CAP was estimated using the Dakin equation. The results indicated that the thermal decomposition of CAP is a three-step process, and the first mass loss stage is to lose pentyl formate. The initial decomposition temperature in either nitrogen or air is 120°C. For decomposition in nitrogen, the E a and A for the initial thermal decomposition are 105.1 kJ mol -1 and 9.12 9 10 11 min -1 , respectively. For decomposition in air, the corresponding E a and A are 105.1 kJ mol -1 and 9.55 9 10 11 min -1 , respectively. The CAP has poor thermal stability under routine temperature.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study on the thermal decomposition of capecitabine

Wang

You

2015

J Therm Anal Calorim

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“…Thermal methods of analysis has been widely used in the coordination chemistry and in the pharmaceutical field to study solid state reactions [10], polymorphism [11], thermal stability [12], drug formulations [13], purity [14], reaction kinetics [15], evolved gas analysis by coupled TG-FTIR [16,17] and other properties of solid compounds used in pharmaceutical industry.…”

Section: Introductionmentioning

confidence: 99%

Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen

et al. 2016

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a b s t r a c tSolid-state [La(Nap) 3 (H 2 O)], in which Nap is naproxen have been synthesized. Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC), powder X-ray diffractometry (XRD), elemental analysis, complexometric titration, middle (MIR) and near (NIR) infrared region spectroscopy were used to characterize this compound and confirm the proposed stoichiometry. The experimental results provided information concerning the chemical composition, dehydration, coordination modes of the ligand, crystallinity of the sample, thermal behavior, thermal decomposition and polymorphism. Theoretical calculations helped in the assignment of the MIR vibrational bands and in the understanding of the coordination mode of the ligands. Cyclic DSC and XRD in different temperatures demonstrated that the complex presents five temperature dependent polymorphic forms. MIR spectroscopy suggest that the naproxen coordinates through the carboxylate group as a chelating ligand.[La(Nap) 3 (H 2 O)] showed lower cell cytotoxicity in comparison to naproxen. The compound increased the production of pro-inflammatory metabolites, such as TNF-␣, IL-1␤ and H 2 O 2 , and decreased an IL-8 level, that interferes in the trafficking of inflammatory cells.

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“…Thermal methods of analysis have been widely used in the pharmaceutical and food areas to detect the thermal stability [11], evaluation of the thermal decomposition kinetics [12], and gaseous products of the thermal decomposition [13], solid-state reactions [14], and as one of the main methods in the detection of polymorphic forms [6].…”

Section: Introductionmentioning

confidence: 99%

Polymorphism in propyl gallate recrystallized with acetone

Gálico

Nova

Bannach

2016

J Therm Anal Calorim

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A new polymorphic form of the synthetic antioxidant propyl gallate was obtained by the recrystallization of the compound in acetone. The new form was characterized by thermogravimetry, differential scanning calorimetry, X-ray powder diffractometry, and near-and middle-infrared region spectroscopy. While the commercial form of propyl gallate starts to melt at 145°C with the maximum temperature of the peak at 150°C, the recrystallized form starts to melt at 140°C with the maximum temperature of the peak at 148.8°C. The two forms differ much in the X-ray powder diffractograms pattern, confirming the change in the longdistance interactions in both forms but the near-and middleinfrared region spectroscopy shows that no difference occurs in the inter-and intramolecular interactions.

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Thermal stability and thermal decomposition of the antihypertensive drug amlodipine besylate

Cited by 26 publications

References 23 publications

Study on the thermal decomposition of capecitabine

Study on the thermal decomposition of capecitabine

Thermal, spectroscopic and in vitro biological studies of the lanthanum complex of naproxen

Polymorphism in propyl gallate recrystallized with acetone

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