Thermal stimuli-responsive topical platform based on copaiba oil-resin: Design and performance upon ex-vivo human skin

Campanholi, Katieli da Silva Souza; Gonçalves, Renato Sonchini; Silva, Jéssica Bassi da; Santos, Rafaela Said dos; Oliveira, Mariana Carla de; Ferreira, Sabrina Barbosa de Souza; Castro-Hoshino, Lidiane Vizioli de; Balbinot, Rodolfo Bento; Lazarin-Bidóia, Danielle; Baesso, Mauro Luciano; Bruschi, Marcos Luciano; Nakamura, Celso V.; Caetano, Wilker

doi:10.1016/j.molliq.2022.119625

Cited by 7 publications

(13 citation statements)

References 98 publications

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“…Considering that the ECO formulation contains 20% of COR mass, the similarity between the COR and ECO spectra ( Figure 2 A) demonstrates the efficiency of ECO in releasing the oil-resin constituents at higher concentrations than COR, as shown by the insert in Figure 2 A. These behaviors, and the C934P/F127 mixture’s signals on the dermis, indicate that the polymer blend acted as a skin permeation promoter [ 10 , 25 , 26 ]. The emollient properties of the oil-resin also favor cutaneous permeation by intrinsic skin mechanisms.…”

Section: Resultsmentioning

confidence: 93%

“…Copaiba oil-resin (COR) has been highlighted as a natural anti-inflammatory for treating skin diseases [ 5 , 6 ]. Studies show benefits in the use of COR for mastitis treatment due to its broad-spectrum antibiotic effect [ 4 , 6 , 7 , 8 , 9 , 10 ]. Furthermore, COR has a healing [ 11 , 12 ] and tissue repair effect [ 13 ], which encourages the development of COR formulations for topical therapies.…”

Section: Introductionmentioning

confidence: 99%

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Copaiba Oil-Based Emulsion as a Natural Chemotherapeutic Agent for the Treatment of Bovine Mastitis: In Vivo Studies

et al. 2023

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Copaiba oil-resin (COR) extracted from Copaifera reticulata Ducke has been used as a natural chemotherapeutic agent for a wide range of therapeutic applications. This study presents an emulgel design with a high concentration of COR, designed to prevent and treat mastitis. The COR was stabilized in a gel matrix constituted by carbopol C934P and Pluronic® F127 (ECO formulation) ratios. The permeation study of ECO was accessed by Fourier transform infrared photoacoustic spectroscopy (FTIR-PAS). The results reveal a high capacity of ECO to permeate deep skin layers. Dairy cows with a history of mastitis were used as in vivo models and exposed to ECO treatment. Monitoring of the teat’s inflammatory response showed that ECO effectively prevents mastitis. Furthermore, the ECO formulation was able to form a thin film gel on the application side, preventing fly proliferation and significantly reducing the pathogen load. This study reveals a drug that can used as an alternative application for mastitis in human or veterinary clinics.

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Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Copaiba Oil-Based Emulsion as a Natural Chemotherapeutic Agent for the Treatment of Bovine Mastitis: In Vivo Studies

et al. 2023

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“…The oil was extracted from holes drilled into the trunks of trees with a circumference greater than 1.20 m. The average collection was up to 1 L of oil resin from a selected tree, respecting the plant's capacity. The hole was closed immediately after collection, remaining in this condition for 3 years, when a new collection in the same tree became viable [38].…”

Section: Copaifera Reticulata Obtentionmentioning

confidence: 99%

“…The recognition of its potential led to the classification of CO as a medicinal plant of interest to the Brazilian Public Health System (SUS) and approval by the Food and Drug Administration (FDA) as a phytotherapeutic medicine [35,36]. Our research group has shown benefits in using copaiba oil from the C. reticulata genus, a natural product of northern Brazil [37,38].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, F127 is a triblock micellar copolymer described as poly(ethylene oxide) (EO) and poly(propylene oxide) (PO) blocks, arranged as EO 99 PO 67 EO 99 [41]. F127 unimers act as permeation promoters of Copaifera reticulata Ducke [38] and lead to Chls monomerization [9,42]. Therefore, this study identifies a polymer blend with therapeutic effect through the combination of k-car polysaccharide and F127 copolymer, with the aim of providing Pharmaceutics 2022, 14, 2580 3 of 21 auxiliary healing and bactericidal activity to the incorporated drugs (phytotherapeutic gels; Phy-gel).…”

Section: Introductionmentioning

confidence: 99%

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Photo-Phytotherapeutic Gel Composed of Copaifera reticulata, Chlorophylls, and k-Carrageenan: A New Perspective for Topical Healing

et al. 2022

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Chronic wound healing represents an impactful financial burden on healthcare systems. In this context, the use of natural products as an alternative therapy reduces costs and maintains effectiveness. Phytotherapeutic gels applied in photodynamic therapy (PDT) have been developed to act as topical healing medicines and antibiotics. The bioactive system is composed of Spirulina sp. (source of chlorophylls) and Copaifera reticulata oil microdroplets, both incorporated into a polymeric blend constituted by kappa-carrageenan (k-car) and F127 copolymer, constituting a system in which all components are bioactive agents. The flow behavior and viscoelasticity of the formulations were investigated. The photodynamic activity was accessed from studies of the inactivation of Staphylococcus aureus bacteria, the main pathogen of hospital relevance. Furthermore, in vivo studies were conducted using eighteen rabbits with dermatitis (grade III and IV) in both paws. The gels showed significant antibiotic potential in vitro, eliminating up to 100% of S. aureus colonies in the presence or absence of light. The k-car reduced 41% of the viable cells; however, its benefits were enhanced by adding chlorophyll and copaiba oil. The animals treated with the phytotherapeutic medicine showed a reduction in lesion size, with healing and re-epithelialization verified in the histological analyses. The animals submitted to PDT displayed noticeable improvement, indicating this therapy’s viability for ulcerative and infected wounds. This behavior was not observed in the iodine control treatment, which worsened the animals’ condition. Therefore, gel formulations were a viable alternative for future pharmaceutical applications, aiming at topical healing.

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Environmentally responsive systems for topical administration of copaiba oil-resin: The effect of carbomer 974P on the mechanical, rheological, drug release and skin permeation

Dano,

de Oliveira,

dos Santos

et al. 2024

Journal of Drug Delivery Science and Technology

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Thermal stimuli-responsive topical platform based on copaiba oil-resin: Design and performance upon ex-vivo human skin

Cited by 7 publications

References 98 publications

Copaiba Oil-Based Emulsion as a Natural Chemotherapeutic Agent for the Treatment of Bovine Mastitis: In Vivo Studies

Copaiba Oil-Based Emulsion as a Natural Chemotherapeutic Agent for the Treatment of Bovine Mastitis: In Vivo Studies

Photo-Phytotherapeutic Gel Composed of Copaifera reticulata, Chlorophylls, and k-Carrageenan: A New Perspective for Topical Healing

Environmentally responsive systems for topical administration of copaiba oil-resin: The effect of carbomer 974P on the mechanical, rheological, drug release and skin permeation

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