Thermo-responsive drug release from self-assembled micelles of brush-like PLA/PEG analogues block copolymers

Hu, Yanfei; Darcos, Vincent; Monge, Sophie; Li, Suming

doi:10.1016/j.ijpharm.2015.06.020

Cited by 58 publications

(30 citation statements)

References 41 publications

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“…According to the literatures, the compositions of temperature sensitive polymers can be chosen from poly(N-Isopropyl acrylamide) PNIPAM) [17,18], poly(N,N-Diethylaminoethyl methacrylate) (DEAM) [19], poly(2,5-Diphenyloxazole) (PPO) [20], poly(ethylene oxide) (PEO) [21], poly(dimethylaminoethyl methacrylate) ( P D M A E M A ) [ 2 2 ] , p o l y ( 2 -( 2 -m e t h o x y e t h o x y ) ethylmethacrylate) (PMEO 2 MA) and poly(oligo (ethylene glycol) methacrylate) (POEGMA) [23][24][25][26], and so on. Among these multitudinous feedstocks, MEO 2 MA and OEGMA could be randomly composed of copolymer P(MEO 2 MA-co-OEGMA) with hydrophilic and temperature responsive as PEG analogues.…”

Section: Introductionmentioning

confidence: 99%

“…Among these multitudinous feedstocks, MEO 2 MA and OEGMA could be randomly composed of copolymer P(MEO 2 MA-co-OEGMA) with hydrophilic and temperature responsive as PEG analogues. By adujsted the variations of the feed ratio of the MEO 2 MA and OEGMA comonomers in copolymerization process, the temperature responsive polymers that present lower critical solution temperature (LCST) values vary from 26 to 90°C can be easily realized [23][24][25][26]. The copolymer's LCST values were determined delicately by the balance between hydrophilic and hydrophobic moieties along with H-bond formation of the hydrophilic oligo(ethylene glycol) side chains in P(MEO 2 MA-co-OEGMA) with the solvent water molecules [27].…”

Section: Introductionmentioning

confidence: 99%

“…The polymer P(MEO 2 MA-co-OEGMA) possess so much attractive properties like temperature sensitive, biocompatible, hydrophilic, nontoxicity and by Food and Drug Administration (FDA) approved, etc. Thus, this kind of polymer has been widely investigated in potential applications as drug delivery, tissue engineering, materials science and biotechnology [23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

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Novel amphiphilic temperature responsive graft copolymers PCL-g-P(MEO2MA-co-OEGMA) via a combination of ROP and ATRP: synthesis, characterization, and sol-gel transition

Liu

Guang

et al. 2016

J Polym Res

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A series of well-defined novel amphiphilic temperature-responsive graft copolymers containing PCL analogues P(αClεCL-co-εCL) as the hydrophobic backbone, and the hydrophilic side-chain PEG analogues P(MEO 2 MAco-OEGMA), designated as P(αClεCL-co-εCL)-g-P(MEO 2 MA-co-OEGMA) have been prepared via a combination of ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). The composition and structure of these copolymers were characterized by 1 H NMR and GPC analyses. The self-assembly behaviors of these amphiphilic graft copolymers were investigated by UV transmittance, a fluorescence probe method, dynamic light scattering (DLS) and transmission electron microscopy (TEM) analyses. The results showed that the graft copolymers exhibited the good solubility in water, and was given the low critical temperature (LCST) at 35(±1)°C, which closed to human physiological temperature. The critical micelle concentrations (CMC) of P(αClεCL-co-εCL)-g-P(MEO 2 MAco-OEGMA) in aqueous solution were investigated to be 2.0 × 10 −3 , 9.1 × 10 −4 and 1.5 × 10 −3 mg·mL −1 , respectively. The copolymer could self-assemble into sphere-like aggregates in aqueous solution with diverse sizes when changing the environmental temperature. The vial inversion test demonstrated that the graft copolymers could trigger the sol-gel transition which also depended on the temperature.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel amphiphilic temperature responsive graft copolymers PCL-g-P(MEO2MA-co-OEGMA) via a combination of ROP and ATRP: synthesis, characterization, and sol-gel transition

Liu

Guang

et al. 2016

J Polym Res

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“…Additionally, the size distributions were rather broad (PDI > 0.2), which should be ascribed to the copolymer polydispersity and/or the presence of micellar clusters. Furthermore, as shown in Figure , the size distribution of G 35 ((M‐ stat ‐O) 90 ) 2 sample displays a trimodal distribution with a highest PDI value (0.515), and this phenomenon also appeared in Mori's and Hu's work …”

Section: Resultsmentioning

confidence: 71%

A novel thermosensitive triblock copolymer from 100% renewably sourced poly(trimethylene ether) glycol

Zhang

Luan

Wang

2017

J of Applied Polymer Sci

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Bio-based amphiphilic triblock copolymers with 100% renewably sourced poly(trimethylene ether) glycol (PO3G) as the hydrophobic blocks and statistical copolymer of 2-(2-methoxyethoxy)ethyl methacrylate (MEO 2 MA) and oligo(ethylene glycol)methacrylate (OEGMA) [P(MEO 2 MA-stat-OEGMA)] as the hydrophilic blocks are synthesized and characterized. It is found that the molar ratio of MEO 2 MA/OEGMA among the resulting copolymers is approximately 70/30. The degree of polymerization (DP) of P(MEO 2 MA-stat-OEGMA) block ranges from 16 to 90, and the DP of PO3G block is fixed at 35. The amphiphilic copolymers could form core-shell micelles self-assembly in aqueous solution at low concentrations, and the micelles are in spherical shape with sizes varying from 121 to 188 nm. With the increasing length of hydrophilic blocks, the critical micelle concentration increases from 2.15 to 13.8 mg L 21 , and the lower critical solution temperature improves from 32.5 to 38.4 8C. The in vitro doxorubicin (DOX) release study shows that all DOX-loaded micelles have a higher release rate at 37 8C than that at 25 8C. Cytotoxicity test reveals that the blank micelles are nearly nontoxic. These results indicate that the block copolymer micelles containing 100% renewably sourced PO3G can serve as a potential drug delivery carrier.

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“…Many studies revealed prolonged release of all drugs in spite of an initial burst. Similarly, in the case of our PTX‐loaded micelles, PTX exhibits a burst release in the first 24 h ( Figure b), followed by a slower release (Figure a).…”

Section: Resultsmentioning

confidence: 99%

PLLA‐Grafted Gelatin Amphiphilic Copolymer and Its Self‐Assembled Nano Carrier for Anticancer Drug Delivery

Fan

et al. 2019

Macro Chemistry & Physics

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A series of poly(l‐lactide)‐grafted gelatin (Gel‐g‐PLLA) copolymers are synthesized by coupling the amino groups of gelatin with different molar masses and the carboxyl endgroup of poly(l‐lactide) in the presence of 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide hydrochloride and N‐hydroxysuccinimide. Fourier transform infrared and nuclear magnetic resonance (1H NMR) data confirm the successful bonding between gelatin and PLLA. Self‐assembled micelles of copolymers are prepared by using the direct dissolution method. The size and micellar morphology are determined from dynamic light scattering as well as transmission electron microscopy measurements. Meanwhile, in vitro drug release reveals that Gel‐g‐PLLA micelles show excellent sustained‐release properties when used as the carrier of the anticancer drug paclitaxel. A burst release of about 70% is observed in the first 24 h. All these features, together with the outstanding biocompatibility, make Gel‐g‐PLLA micelles a promising drug carrier for cancer therapy.

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Thermo-responsive drug release from self-assembled micelles of brush-like PLA/PEG analogues block copolymers

Cited by 58 publications

References 41 publications

Novel amphiphilic temperature responsive graft copolymers PCL-g-P(MEO2MA-co-OEGMA) via a combination of ROP and ATRP: synthesis, characterization, and sol-gel transition

Novel amphiphilic temperature responsive graft copolymers PCL-g-P(MEO2MA-co-OEGMA) via a combination of ROP and ATRP: synthesis, characterization, and sol-gel transition

A novel thermosensitive triblock copolymer from 100% renewably sourced poly(trimethylene ether) glycol

PLLA‐Grafted Gelatin Amphiphilic Copolymer and Its Self‐Assembled Nano Carrier for Anticancer Drug Delivery

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